Literature DB >> 2579657

Mammalian tachykinin-induced hydrolysis of inositol phospholipids in rat brain slices.

J C Hunter, M Goedert, R D Pinnock.   

Abstract

The mammalian tachykinins substance K, neuromedin K and substance P stimulated inositol phospholipid hydrolysis in paired coronal sections through the rat brain. In contrast, none of these peptides had any effect on either basal or forskolin-stimulated cyclic AMP levels. The present results therefore implicate inositol phospholipid hydrolysis as a possible second messenger system mediating the effects of substance K and neuromedin K in addition to substance P.

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Year:  1985        PMID： 2579657     DOI： 10.1016/s0006-291x(85)80205-9

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  2 in total

Review 1.  Neurokinin-1 receptor: functional significance in the immune system in reference to selected infections and inflammation.

Authors:  Steven D Douglas; Susan E Leeman
Journal:  Ann N Y Acad Sci       Date:  2010-11-22       Impact factor: 5.691

2.  Suppression of airway hyperresponsiveness induced by ovalbumin sensitisation and RSV infection with Y-27632, a Rho kinase inhibitor.

Authors:  K Hashimoto; R S Peebles; J R Sheller; K Jarzecka; J Furlong; D B Mitchell; T V Hartert; B S Graham
Journal:  Thorax       Date:  2002-06       Impact factor: 9.139
  2 in total

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