Literature DB >> 25796438

The regulatory roles of ROCK and MRCK kinases in the plasticity of cancer cell migration.

Vijay Pralhad Kale1, Jeremy A Hengst1, Dhimant H Desai1, Shantu G Amin1, Jong K Yun2.   

Abstract

Metastatic cancer cells show great plasticity in their migratory mechanisms. In this review we briefly describe the signal transduction pathways associated with the ROCK and MRCK kinases and their roles in cancer cell migration and in its plasticity. With respect to therapeutic strategies targeting metastatic cancers, selectively blocking a single target, such as ROCK or MRCK, can induce alternate modes of cancer cell migration (i.e. plasticity) making the treatment ineffective. To address the problem of plasticity, we will discuss the strategy of simultaneous targeting of both ROCK and MRCK as an effective anti-metastatic therapeutics.
Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Entities:  

Keywords:  Anticancer therapeutics; Cell migration plasticity; MRCK; Polypharmacology; ROCK and MRCK inhibitors; Rho kinase

Mesh：

Substances：

Year:  2015        PMID： 25796438     DOI： 10.1016/j.canlet.2015.03.017

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  17 in total

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10.  ROCK Inhibition Promotes Attachment, Proliferation, and Wound Closure in Human Embryonic Stem Cell-Derived Retinal Pigmented Epithelium.

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