External cervical resorption associated with the use of bisphosphonates: a case series.

Although the pathogenesis and etiology of external cervical resorption (ECR) are not well understood, several predisposing factors have been reported to potentially contribute toward the initiation of ECR. However, a potential link between systemic medication and ECR has not been reported. Bisphosphonates (BSPs) are 1 group of these medications (the amino-containing BSP), which are associated with an acute-phase response and the release of proinflammatory cytokines, which could be associated with the initiation of ECR. Therefore, a possible causal link between BSPs and ECR could be drawn.