Literature DB >> 25795991

Bioidentical hormones, menopausal women, and the lure of the "natural" in U.S. anti-aging medicine.

Jennifer R Fishman1, Michael A Flatt2, Richard A Settersten3.   

Abstract

In 2002, the Women's Health Initiative, a large-scale study of the safety of hormone replacement therapy (HRT) for women conducted in the United States, released results suggesting that use of postmenopausal HRT increased women's risks of stroke and breast cancer. In the years that followed, as rates of HRT prescription fell, another hormonal therapy rose in its wake: bioidentical hormone replacement therapy (BHRT). Anti-aging clinicians, the primary prescribers of BHRT, tout it as a safe and effective alternative to treat menopausal symptoms and, moreover, as a preventative therapy for age-related diseases and ailments. Through in-depth interviews with 31 U.S.-based anti-aging clinicians and 25 female anti-aging patients, we analyze attitudes towards BHRT. We illustrate how these attitudes reveal broader contemporary values, discourses, and discomforts with menopause, aging, and biomedicine. The attraction to and promise of BHRT is rooted in the idea that it is a "natural" therapy. BHRT is given both biomedical and embodied legitimacy by clinicians and patients because of its purported ability to become part of the body's "natural" processes. The normative assumption that "natural" is inherently "good" not only places BHRT beyond reproach, but transforms its use into a health benefit. The clinical approach of anti-aging providers also plays a role by validating patients' embodied experiences and offering a "holistic" solution to their symptoms, which anti-aging patients see as a striking contrast to their experiences with conventional biomedical health care. The perceived virtues of BHRT shed light on the rhetoric of anti-aging medicine and a deeply complicated relationship between conventional biomedicine, hormonal technologies, and women's bodies.
Copyright © 2015 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Aging; Anti-aging; Bioidentical hormones; Biomedicine; Hormone replacement therapy; Menopause; United States; Women's health

Mesh:

Substances:

Year:  2015        PMID: 25795991      PMCID: PMC4400226          DOI: 10.1016/j.socscimed.2015.02.027

Source DB:  PubMed          Journal:  Soc Sci Med        ISSN: 0277-9536            Impact factor:   4.634


  27 in total

1.  Hormone replacement therapy: women's decision-making process.

Authors:  J B Jones
Journal:  Soc Work Health Care       Date:  1999

Review 2.  Hormone replacement therapy, cancer, controversies, and women's health: historical, epidemiological, biological, clinical, and advocacy perspectives.

Authors:  Nancy Krieger; Ilana Löwy; Robert Aronowitz; Judyann Bigby; Kay Dickersin; Elizabeth Garner; Jean-Paul Gaudillière; Carolina Hinestrosa; Ruth Hubbard; Paula A Johnson; Stacey A Missmer; Judy Norsigian; Cynthia Pearson; Charles E Rosenberg; Lynn Rosenberg; Barbara G Rosenkrantz; Barbara Seaman; Carlos Sonnenschein; Ana M Soto; Joe Thornton; George Weisz
Journal:  J Epidemiol Community Health       Date:  2005-09       Impact factor: 3.710

3.  Anti-aging medicine: a patient/practitioner movement to redefine aging.

Authors:  Courtney Everts Mykytyn
Journal:  Soc Sci Med       Date:  2005-07-22       Impact factor: 4.634

4.  In the vanguard of biomedicine? The curious and contradictory case of anti-ageing medicine.

Authors:  Jennifer R Fishman; Richard A Settersten; Michael A Flatt
Journal:  Sociol Health Illn       Date:  2009-12-09

5.  Bioidentical hormone therapy: a panacea that lacks supportive evidence.

Authors:  Lisa A Boothby; Paul L Doering
Journal:  Curr Opin Obstet Gynecol       Date:  2008-08       Impact factor: 1.927

6.  Effect of the Women's Health Initiative on women's decisions to discontinue postmenopausal hormone therapy.

Authors:  Bruce Ettinger; Deborah Grady; Anna N A Tosteson; Alice Pressman; Judith L Macer
Journal:  Obstet Gynecol       Date:  2003-12       Impact factor: 7.661

7.  Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women's Health Initiative randomized controlled trial.

Authors:  Jacques E Rossouw; Garnet L Anderson; Ross L Prentice; Andrea Z LaCroix; Charles Kooperberg; Marcia L Stefanick; Rebecca D Jackson; Shirley A A Beresford; Barbara V Howard; Karen C Johnson; Jane Morley Kotchen; Judith Ockene
Journal:  JAMA       Date:  2002-07-17       Impact factor: 56.272

Review 8.  Bioidentical hormone therapy: a review of the evidence.

Authors:  Michael Cirigliano
Journal:  J Womens Health (Larchmt)       Date:  2007-06       Impact factor: 2.681

9.  Differences in perceived risks and benefits of herbal, over-the-counter conventional, and prescribed conventional, medicines, and the implications of this for the safe and effective use of herbal products.

Authors:  Natalie Lynch; Dianne Berry
Journal:  Complement Ther Med       Date:  2006-08-24       Impact factor: 2.446

10.  Bioidentical hormones for menopausal hormone therapy: variation on a theme.

Authors:  Adriane Fugh-Berman; Jenna Bythrow
Journal:  J Gen Intern Med       Date:  2007-03-07       Impact factor: 5.128

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  10 in total

Review 1.  Update on primary ovarian insufficiency.

Authors:  Meghan Hewlett; Shruthi Mahalingaiah
Journal:  Curr Opin Endocrinol Diabetes Obes       Date:  2015-12       Impact factor: 3.243

2.  Interaction between cardiovascular autonomic control and sex hormones in perimenopausal women under menopausal hormone therapy.

Authors:  Anton R Kiselev; Irina W Neufeld; Irina V Bobyleva; Mikhail D Prokhorov; Anatoly S Karavaev
Journal:  Cardiovasc Endocrinol Metab       Date:  2018-08-15

3.  Physiological Concentrations of Cimicifuga racemosa Extract Do Not Affect Expression of Genes Involved in Estrogen Biosynthesis and Action in Endometrial and Ovarian Cell Lines.

Authors:  Maša Sinreih; Klara Gregorič; Kristina Gajser; Tea Lanišnik Rižner
Journal:  Biomolecules       Date:  2022-04-05

4.  Prescribing of FDA-approved and compounded hormone therapy differs by specialty.

Authors:  Ginger D Constantine; David F Archer; Shelli Graham; Brian A Bernick; Sebastian Mirkin
Journal:  Menopause       Date:  2016-10       Impact factor: 2.953

5.  The REJOICE trial: a phase 3 randomized, controlled trial evaluating the safety and efficacy of a novel vaginal estradiol soft-gel capsule for symptomatic vulvar and vaginal atrophy.

Authors:  Ginger D Constantine; James A Simon; James H Pickar; David F Archer; Harvey Kushner; Brian Bernick; Gina Gasper; Shelli Graham; Sebastian Mirkin
Journal:  Menopause       Date:  2017-04       Impact factor: 2.953

6.  Evaluation of clinical meaningfulness of estrogen plus progesterone oral capsule (TX-001HR) on moderate to severe vasomotor symptoms.

Authors:  Ginger D Constantine; Dennis A Revicki; Risa Kagan; James A Simon; Shelli Graham; Brian Bernick; Sebastian Mirkin
Journal:  Menopause       Date:  2019-05       Impact factor: 2.953

7.  Estradiol and progesterone bioavailability for moderate to severe vasomotor symptom treatment and endometrial protection with the continuous-combined regimen of TX-001HR (oral estradiol and progesterone capsules).

Authors:  Rogerio A Lobo; James Liu; Frank Z Stanczyk; Ginger D Constantine; James H Pickar; Annette M Shadiack; Brian Bernick; Sebastian Mirkin
Journal:  Menopause       Date:  2019-07       Impact factor: 2.953

8.  Why women choose compounded bioidentical hormone therapy: lessons from a qualitative study of menopausal decision-making.

Authors:  Jennifer Jo Thompson; Cheryl Ritenbaugh; Mark Nichter
Journal:  BMC Womens Health       Date:  2017-10-02       Impact factor: 2.809

9.  Oral 17β-estradiol/progesterone (TX-001HR) and quality of life in postmenopausal women with vasomotor symptoms.

Authors:  James A Simon; Andrew M Kaunitz; Robin Kroll; Shelli Graham; Brian Bernick; Sebastian Mirkin
Journal:  Menopause       Date:  2019-05       Impact factor: 2.953

10.  Increased Incidence of Endometrial Cancer Following the Women's Health Initiative: An Assessment of Risk Factors.

Authors:  Ginger D Constantine; Grant Kessler; Shelli Graham; Steven R Goldstein
Journal:  J Womens Health (Larchmt)       Date:  2018-11-28       Impact factor: 2.681

  10 in total

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