Júlia Figueiredo Machado1, Vanessa Oya2, Cláudio Saddy Rodrigues Coy3, André Moreno Morcillo2, Silvana Dalge Severino2, Chao Wu4, Valdemiro Carlos Sgarbieri5, Maria Marluce dos Santos Vilela2. 1. Center for Investigation in Pediatrics, Pediatrics Department, Medical Sciences Faculty, University of Campinas - UNICAMP, Rua Tessália Vieira de Camargo, 126, CEP 13083-970, Campinas, São Paulo, Brazil.. juliafm83@gmail.com. 2. Center for Investigation in Pediatrics, Pediatrics Department, Medical Sciences Faculty, University of Campinas - UNICAMP, Rua Tessália Vieira de Camargo, 126, CEP 13083-970, Campinas, São Paulo, Brazil.. marluce@fcm.unicamp.br. 3. Gastrocenter - Coloproctology Unit, Surgery Department, Gastrocenter, Medical Sciences Faculty, University of Campinas, Rua Carlos Chagas, 420, CEP 13083- 878, Campinas - São Paulo, Brazil.. marluce@fcm.unicamp.br. 4. Hilmar Cheese Company, Hilmar, CA, USA.. marluce@fcm.unicamp.br. 5. Food Engineering Faculty, University of Campinas - UNICAMP, Rua Monteiro Lobato, 80, CEP 13083-970, Campinas, São Paulo, Brazil.. marluce@fcm.unicamp.br.
Abstract
BACKGROUND:Crohn's disease (CD) is a chronic transmural inflammation of the gastrointestinal tract of unknown cause. Malnutrition associated with active CD has been reduced although obesity has increased. Dietary strategies such as those with high-protein have been proposed to reduce body fat. This study compares the effects of two supplements on the nutritional status of CD patients. MATERIALS AND METHODS:68 CD patients were randomized in two groups: whey protein group (WP) and soy protein group (SP). Using bioimpedance analysis, anthropometry and albumin and pre-albumin dosages the nutritional status was measured before starting the intervention and after 8 and 16 weeks. The disease activity was determined by Crohn's Disease Activity Index and serum C-reactive protein dosage and dietary intake by 24h dietary recalls. RESULTS: Forty-one patients concluded the study and both supplements changed body composition similarly. Triceps skin fold thickness (p< 0.001) and body fat percentage (p=0.001) decreased, whereas mid-arm muscle circumference (p=0.004), corrected arm muscle area (p=0.005) and body lean percentage (p=0.001) increased. CONCLUSIONS:For Crohn's disease patients undergoinganti TNF-alpha and azatioprine therapies, supplementation with whey and soy proteins changes body composition through reduction of body fat and thus contributes to control inflammation. Copyright AULA MEDICA EDICIONES 2014. Published by AULA MEDICA. All rights reserved.
RCT Entities:
BACKGROUND:Crohn's disease (CD) is a chronic transmural inflammation of the gastrointestinal tract of unknown cause. Malnutrition associated with active CD has been reduced although obesity has increased. Dietary strategies such as those with high-protein have been proposed to reduce body fat. This study compares the effects of two supplements on the nutritional status of CDpatients. MATERIALS AND METHODS: 68 CDpatients were randomized in two groups: whey protein group (WP) and soy protein group (SP). Using bioimpedance analysis, anthropometry and albumin and pre-albumin dosages the nutritional status was measured before starting the intervention and after 8 and 16 weeks. The disease activity was determined by Crohn's Disease Activity Index and serum C-reactive protein dosage and dietary intake by 24h dietary recalls. RESULTS: Forty-one patients concluded the study and both supplements changed body composition similarly. Triceps skin fold thickness (p< 0.001) and body fat percentage (p=0.001) decreased, whereas mid-arm muscle circumference (p=0.004), corrected arm muscle area (p=0.005) and body lean percentage (p=0.001) increased. CONCLUSIONS: For Crohn's diseasepatients undergoing anti TNF-alpha and azatioprine therapies, supplementation with whey and soy proteins changes body composition through reduction of body fat and thus contributes to control inflammation. Copyright AULA MEDICA EDICIONES 2014. Published by AULA MEDICA. All rights reserved.