Deborah Cristina Landi Masquio1, Aline de Piano Ganen2, Raquel Munhoz da Silveira Campos3, Priscila de Lima Sanches4, Flávia Campos Corgosinho5, Danielle Caranti6, Lian Tock7, Marco Túlio de Mello8, Sergio Tufik9, Ana R Dâmaso10. 1. Post-Graduate Program of Nutrition, Universidade Federal de São Paulo (UNIFESP), São Paulo-SP.. deborahmasquio@yahoo.com.br. 2. Post-Graduate Program of Nutrition, Universidade Federal de São Paulo (UNIFESP), São Paulo-SP.. aline.depiano@gmail.com. 3. Post-Graduate Program of Nutrition, Universidade Federal de São Paulo (UNIFESP), São Paulo-SP.. raquelmunhoz@hotmail.com. 4. Post-Graduate Program of Nutrition, Universidade Federal de São Paulo (UNIFESP), São Paulo-SP.. prisan27@yahoo.com.br. 5. Post-Graduate Program of Nutrition, Universidade Federal de São Paulo (UNIFESP), São Paulo-SP.. flavia@cepebr.org. 6. Post Graduate Program of Interdisciplinary Health Science, Universidade Federal de São Paulo (UNIFESP), Santos-SP.. danielle.caranti@unifesp.br. 7. Weight Science, São Paulo-SP.. lionto@uol.com.br. 8. Post-Graduate Program of Nutrition, Universidade Federal de São Paulo (UNIFESP), São Paulo-SP.. tmello@demello.net. 9. Department of Psychobiology Universidade Federal de São Paulo (UNIFESP), São Paulo-SP. Brasil.. s.tufik@unifesp.br. 10. Post-Graduate Program of Nutrition, Universidade Federal de São Paulo (UNIFESP), São Paulo-SP. Post Graduate Program of Interdisciplinary Health Science, Universidade Federal de São Paulo (UNIFESP), Santos-SP.. ana.damaso@unifesp.br.
Abstract
INTRODUCTION: Metabolic syndrome (MetS) is a constellation of metabolic alteration related to abdominal obesity, inflammation and insulin resistance, which increase cardiovascular disease and mortality. The aims of the present study were to identify the prevalence of comorbidities and altered parameters in obese adolescents with and without MetS, and determine cut-off points of waist circumference to predict MetS. METHODS: 195 obese adolescents were recruited and divided according to MetS diagnosis based on IDF criteria. Blood analyses of glucose, lipids, liver enzymes, adiponectin and leptin were measured. Insulin resistance was assessed by HOMA-IR, QUICKI and HOMA-AD. Visceral, subcutaneous and hepatic fat were ultrasonography obtained. Body composition was estimated by BOD POD system. RESULTS: We observed a prevalence of 25% of MetS (n=50). The MetS group presented significant higher body mass, BMI, body fat (kg), free-fat mass (kg), waist circumference, visceral fat, glucose, insulin, insulin resistance, total-cholesterol, LDL-c, VLDL-c, triglycerides, liver enzymes, non-alcoholic fatty liver disease (NAFLD) and blood pressure. Significant lower QUICKI and adiponectin in MetS group were noted. MetS girls presented significant higher leptin/adiponectin ratio compared to Non-MetS girls. Cut-off points of 111.5 cm for boys and 104.6 cm for girls of waist circumference were suggested to predict metabolic syndrome. Moreover, waist circumference was positive correlated with visceral fat and the number of metabolic syndrome parameters. CONCLUSION: MetS group presented significant higher metabolic alterations and inflammation compared to Non-MetS group. Waist circumference is considered an anthropometric measure predictor of metabolic syndrome in obese adolescents, being useful in clinical practice. Copyright AULA MEDICA EDICIONES 2014. Published by AULA MEDICA. All rights reserved.
INTRODUCTION:Metabolic syndrome (MetS) is a constellation of metabolic alteration related to abdominal obesity, inflammation and insulin resistance, which increase cardiovascular disease and mortality. The aims of the present study were to identify the prevalence of comorbidities and altered parameters in obese adolescents with and without MetS, and determine cut-off points of waist circumference to predict MetS. METHODS: 195 obese adolescents were recruited and divided according to MetS diagnosis based on IDF criteria. Blood analyses of glucose, lipids, liver enzymes, adiponectin and leptin were measured. Insulin resistance was assessed by HOMA-IR, QUICKI and HOMA-AD. Visceral, subcutaneous and hepatic fat were ultrasonography obtained. Body composition was estimated by BOD POD system. RESULTS: We observed a prevalence of 25% of MetS (n=50). The MetS group presented significant higher body mass, BMI, body fat (kg), free-fat mass (kg), waist circumference, visceral fat, glucose, insulin, insulin resistance, total-cholesterol, LDL-c, VLDL-c, triglycerides, liver enzymes, non-alcoholic fatty liver disease (NAFLD) and blood pressure. Significant lower QUICKI and adiponectin in MetS group were noted. MetS girls presented significant higher leptin/adiponectin ratio compared to Non-MetS girls. Cut-off points of 111.5 cm for boys and 104.6 cm for girls of waist circumference were suggested to predict metabolic syndrome. Moreover, waist circumference was positive correlated with visceral fat and the number of metabolic syndrome parameters. CONCLUSION: MetS group presented significant higher metabolic alterations and inflammation compared to Non-MetS group. Waist circumference is considered an anthropometric measure predictor of metabolic syndrome in obese adolescents, being useful in clinical practice. Copyright AULA MEDICA EDICIONES 2014. Published by AULA MEDICA. All rights reserved.
Authors: Sandro S Almeida; Flavia C Corgosinho; Carlos En Amorim; Marcos F Gregnani; Raquel Ms Campos; Deborah Cl Masquio; Priscila L Sanches; Aline P Ganen; João B Pesquero; Ana R Dâmaso; Marco T Mello; Sergio Tufik; Ronaldo C Araújo Journal: J Renin Angiotensin Aldosterone Syst Date: 2017 Apr-Jun Impact factor: 1.636
Authors: Heloísa Marcelina da Cunha Palhares; Adriana Paula da Silva; Daniela Cristina Silva Resende; Gilberto de Araújo Pereira; Virmondes Rodrigues; Maria de Fátima Borges Journal: Clinics (Sao Paulo) Date: 2017-01-01 Impact factor: 2.365