Carolina Loureiro1, Andrea Godoy2, Alejandro Martínez2, Carmen Campino3, Marlene Aglony4, Rodrigo Bancalari2, Carolina Mendoza2, Jaime Cerda5, Cristian Carvajal3, Pilar Arnaiz6, Carlos Fardella3, Hernan García2. 1. Pediatric Endocrinology Unit. Pontificia Universidad Católica de Chile. Chile. Calourei@gmail.com. 2. Pediatric Endocrinology Unit. Pontificia Universidad Católica de Chile. Chile. hgarciab@gmail.com. 3. Department of Endocrinology. Pontificia Universidad Católica de Chile. Chile. hgarciab@gmail.com. 4. Pediatric Nephrology Unit. Pontificia Universidad Católica de Chile. Chile. hgarciab@gmail.com. 5. Department of Public Health. Pontificia Universidad Católica de Chile. Chile. hgarciab@gmail.com. 6. Pediatric Cardiology Unit. Pontificia Universidad Católica de Chile. Chile. hgarciab@gmail.com.
Abstract
INTRODUCTION: Endothelial inflammation and insulin resistance (IR) begin in childhood and constitute the pathophysiological basis of Metabolic Syndrome (MS). The increase levels in plasma of inflammatory markers such as high sensitive PCR (hsPCR), plasminogen activator inhibitor 1 (PAI-1) and tests suggestive of IR such as Insulin (Ins) and alanine aminotransferase (ALT) have been associated with MS in adults, but have not been studied in children. OBJECTIVES: Correlate the presence of MS and its components with the inflammatory and IR markers seen in the pediatric population. METHODS: Cross-sectional study of 337 children (10,9±9,7 years) whose levels of hsPCR, PAI-1, Ins and ALT were determined, along with their association with MS and its individual components. RESULTS: 37 children had MS (10,4%). The frequency of MS components was: abdominal obesity 38,5%, hypertension (HTN) 21,3%, hypertriglyceridemia 17,8%, HDL 21,3% and hyperglycemia 1,4%. hsPCR, PAI-1, ALT and Ins were higher in the presence of MS and increased progressively when components were came together. CONCLUSIONS: The pediatric population segment with MS had a higher concentration of hsPCR, PAI-1, Ins and ALT.These levels increase proportionally MS components add up, suggesting that even before diagnosis criteria are fulfilled there is a inflammatory state. Copyright AULA MEDICA EDICIONES 2014. Published by AULA MEDICA. All rights reserved.
INTRODUCTION: Endothelial inflammation and insulin resistance (IR) begin in childhood and constitute the pathophysiological basis of Metabolic Syndrome (MS). The increase levels in plasma of inflammatory markers such as high sensitive PCR (hsPCR), plasminogen activator inhibitor 1 (PAI-1) and tests suggestive of IR such as Insulin (Ins) and alanine aminotransferase (ALT) have been associated with MS in adults, but have not been studied in children. OBJECTIVES: Correlate the presence of MS and its components with the inflammatory and IR markers seen in the pediatric population. METHODS: Cross-sectional study of 337 children (10,9±9,7 years) whose levels of hsPCR, PAI-1, Ins and ALT were determined, along with their association with MS and its individual components. RESULTS: 37 children had MS (10,4%). The frequency of MS components was: abdominal obesity 38,5%, hypertension (HTN) 21,3%, hypertriglyceridemia 17,8%, HDL 21,3% and hyperglycemia 1,4%. hsPCR, PAI-1, ALT and Ins were higher in the presence of MS and increased progressively when components were came together. CONCLUSIONS: The pediatric population segment with MS had a higher concentration of hsPCR, PAI-1, Ins and ALT.These levels increase proportionally MS components add up, suggesting that even before diagnosis criteria are fulfilled there is a inflammatory state. Copyright AULA MEDICA EDICIONES 2014. Published by AULA MEDICA. All rights reserved.
Authors: Ariane R de F Rocha; Núbia de S Morais; Silvia E Priore; Sylvia do C C Franceschini Journal: Inflammation Date: 2021-09-21 Impact factor: 4.092