| Literature DB >> 25795695 |
Dominic Murphy1, Georgina Hodgman2, Carron Carson2, Lucy Spencer-Harper2, Mark Hinton2, Simon Wessely3, Walter Busuttil2.
Abstract
OBJECTIVE: Combat Stress, a UK national charity for veterans with mental health problems, has been funded by the National Health Service (NHS) to provide a national specialist service to deliver treatment for post-traumatic stress disorder (PTSD). This paper reports the efficacy of a PTSD treatment programme for UK veterans at 6 months follow-up.Entities:
Keywords: MENTAL HEALTH
Mesh:
Year: 2015 PMID: 25795695 PMCID: PMC4368912 DOI: 10.1136/bmjopen-2014-007051
Source DB: PubMed Journal: BMJ Open ISSN: 2044-6055 Impact factor: 2.692
Figure 1Overview of participants.
Demographic characteristics
| Variable | Number* (%) |
|---|---|
| Total enrolled on ITP | 246 |
| Age group | |
| <35 | 61 (25) |
| 35–44 | 84 (35) |
| >45 | 97 (40) |
| Sex | |
| Male | 241 (98) |
| Female | 5 (2) |
| Education | |
| Low (O Levels or none) | 223 (93) |
| High (A Levels or above) | 17 (7) |
| Relationship status | |
| In a relationship | 130 (53) |
| Single | 113 (47) |
| Employment status | |
| Working | 90 (39) |
| Not working | 143 (62) |
| Financial difficulties | |
| No | 113 (48) |
| Yes | 120 (52) |
| Service | |
| Royal Navy | 27 (11) |
| Army | 204 (84) |
| Royal Air Force | 11 (5) |
| Role in military | |
| Non-combat | 56 (23) |
| Combat | 186 (77) |
| Last rank | |
| Officer | 14 (6) |
| Other ranks | 228 (94) |
| Type of discharge from military | |
| Voluntary | 144 (61) |
| Non-voluntary | 91 (39) |
| Years since left the military | |
| 1–9 | 97 (40) |
| 10–19 | 66 (27) |
| 20–29 | 60 (25) |
| 30+ | 20 (8) |
| Number of deployments to conflicts zones | |
| 1 or 2 | 139 (57) |
| 3+ | 103 (43) |
*Numbers may not add up to 246 because of missing data.
Comparisons of baseline mental health scores between completers and non-completers of the ITP
| Completers | Non-Completers | p Value | |
|---|---|---|---|
| score (95% CI) | score (95% CI) | ||
| PSS-I | 36.4 (35.5 to 37.4) | 35.8 (32.7 to 38.9) | 0.41 |
| IES-R | 56.1 (54.2 to 58.0) | 58.5 (50.9 to 66.0) | 0.69 |
| PHQ-9 | 17.3 (16.6 to 17.9) | 18.0 (14.8 to 21.3) | 0.58 |
| GAD-7 | 15.4 (14.8 to 16.1) | 16.5 (14.0 to 19.0) | 0.42 |
| DAR-5 | 11.3 (10.6 to 11.2) | 12.6 (8.78 to 16.4) | 0.29 |
DAR-5, Dimensions of Anger Reactions; GAD-7, Generalised Anxiety Disorder Assessment; IES-R, Revised Impact of Events Scale; ITP, intensive treatment programme; PHQ-9, Patient Health Questionnaire; PSS-I, PTSD Symptom Scale Interview.
Comparison of sociodemographics characteristics and health outcomes between responders at 6 months and non-responders
| Responder N (%) | Non-responder N (%) | p Value | |
|---|---|---|---|
| 186 (81) | 45 (19) | ||
| Age group | |||
| <35 | 44 (24) | 14 (31) | |
| 35–44 | 64 (35) | 14 (31) | |
| >45 | 76 (41) | 17 (38) | 0.61 |
| Sex | |||
| Male | 182 (98) | 44 (98) | |
| Female | 4 (2) | 1 (2) | 0.98 |
| Education | |||
| Low (O Levels or none) | 168 (92) | 44 (98) | |
| High (A Levels or above) | 14 (8) | 1 (2) | 0.19 |
| Relationship status | |||
| In a relationship | 96 (52) | 24 (53) | |
| Single | 89 (48) | 21 (47) | 0.87 |
| Employment status | |||
| Working | 66 (37) | 19 (44) | |
| Not working | 111 (63) | 24 (56) | 0.41 |
| Financial difficulties | |||
| No | 88 (50) | 21 (48) | |
| Yes | 89 (50) | 23 (52) | 0.81 |
| Health outcomes at admission | N=186 | N=45 | |
| PSS-I | 36.8 (37.7–37.9) | 34.9 (32.8–37.0) | 0.14 |
| PHQ-9 | 17.3 (16.6–18.1) | 17.0 (15.5–18.6) | 0.75 |
| GAD-7 | 15.4 (14.7–16.0) | 15.8 (13.5–18.0) | 0.96 |
| Health outcomes at F/U | N=186 | N=22 | |
| PSS-I | 23.8 (22.1–25.6) | 25.9 (21.3–30.5) | 0.40 |
| PHQ-9 | 13.7 (12.7–14.6) | 12.3 (9.4–15.2) | 0.25 |
| GAD-7 | 12.3 (11.4–13.2) | 10.9 (7.78–14.0) | 0.34 |
GAD-7, Generalised Anxiety Disorder Assessment; PHQ-9, Patient Health Questionnaire; PSS-I, PTSD Symptom Scale Interview.
Health outcomes at 6 months follow-up
| Admission score | 6 months score | Unadjusted model | Adjusted model* | |||||
|---|---|---|---|---|---|---|---|---|
| Mean (SD) | Mean (SD) | β (95% CI) | Rate of change† | β (95% CI) | Rate of change† | |||
| PSS-I | 36.8 (7.56) | 23.8 (12.3) | −13.0 (−14.5 to −11.5) | T1 | −13.0 | −12.9 (−14.5 to −11.4) | T1 | −12.9 |
| T2 | −8.01 | T2 | −8.06 | |||||
| T3 | −3.22 | T3 | −3.21 | |||||
| IES-R | 56.4 (14.8) | 41.1 (20.9) | −16.5 (−19.0 to −14.0) | T1 | −16.5 | −16.8 (−19.3 to −14.3) | T1 | −16.8 |
| T2 | −10.3 | T2 | −10.4 | |||||
| T3 | −4.00 | T3 | −4.00 | |||||
| PHQ-9 | 17.3 (5.04) | 13.7 (6.18) | −4.35 (−5.19 to −3.51) | T1 | −4.35 | −4.20 (−5.06 to −3.34) | T1 | −4.20 |
| T2 | −2.59 | T2 | −2.51 | |||||
| T3 | −0.83 | T3 | −0.82 | |||||
| GAD-7‡ | 15.4 (4.40) | 12.3 (5.73) | −4.65 (−5.38 to −3.91) | T1 | −4.65 | −4.61 (−5.37 to −3.85) | T1 | −4.61 |
| T2 | −2.70 | T2 | −2.66 | |||||
| T3 | −0.74 | T3 | −0.72 | |||||
| DAR-5 | 11.2 (4.81) | 9.7 (6.84) | −3.00 (−3.68 to −2.29) | T1 | −3.00 | −2.95 (−3.67 to −2.23) | T1 | −2.95 |
| T2 | −1.71 | T2 | −1.70 | |||||
| T3 | −0.44 | T3 | −0.44 | |||||
| HONOS | 16.1 (6.46) | 12.3 (7.35) | −6.85 (−7.98 to −5.72) | T1 | −6.85 | −6.84 (−8.02 to −5.66) | T1 | −6.84 |
| T2 | −4.00 | T2 | −4.02 | |||||
| T3 | −1.15 | T3 | −1.19 | |||||
| GAF | 52.5 (7.74) | 60.5 (10.9) | 5.90 (3.97 to 7.82) | T1 | 5.90 | 6.00 (4.06 to 7.93) | T1 | 6.00 |
| T2 | 3.96 | T2 | 4.15 | |||||
| T3 | 2.03 | T3 | 2.29 | |||||
| WSAS | 25.2 (7.68) | 22.4 (9.55) | −3.07 (−4.21 to −1.93) | T1 | −3.07 | −3.35 (−4.50 to −2.20) | T1 | −3.35 |
| T2 | −1.94 | T2 | −2.24 | |||||
| T3 | −0.81 | T3 | −0.99 | |||||
*Adjusted for employment status and age group.
†T1=rate of change between admission and discharge, T2=rate of change between discharge and 6 weeks, T3=rate of change between 6 weeks and 6 months. This do not refer to changes in health scores.
‡Linear model fitted as unable to fit non-linear model.
DAR-5, Dimensions of Anger Reactions; GAD-7, Generalised Anxiety Disorder Assessment; GAF, Global Assessment of Function; HONOS, Health of the Nation Outcome Scales; IES-R, Revised Impact of Events Scale; PSS-I, PTSD Symptom Scale Interview; PTSD, post-traumatic stress disorder; WSAS, Work and Social Adjustment Scale.