| Literature DB >> 25795272 |
Jeannette Cany1, Harry Dolstra1, Nina Shah2.
Abstract
Although the vast majority of experience with umbilical cord blood (CB) centers on hematopoietic reconstitution, a recent surge in the knowledge of CB cell subpopulations as well as advances in ex vivo culture technology have expanded the potential of this rich resource. Because CB has the capacity to generate the entire hematopoietic system, we now have a new source for natural killer, dendritic and T cells for therapeutic use against malignancies. This Review will focus on cellular immunotherapies derived from CB. Expansion techniques, ongoing clinical trials and future directions for this new dimension of CB application are also discussed.Entities:
Keywords: cancer immunotherapy; cellular therapy; cord blood; expansion
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Year: 2015 PMID: 25795272 DOI: 10.1016/j.jcyt.2015.03.005
Source DB: PubMed Journal: Cytotherapy ISSN: 1465-3249 Impact factor: 5.414