E Bouzigon1, R Nadif2, N Le Moual2, M-H Dizier3, H Aschard3, A Boudier4, J Bousquet5, S Chanoine6, C Donnay7, O Dumas2, F Gormand8, B Jacquemin9, J Just10, P Margaritte-Jeannin3, R Matran11, C Pison12, E Rage13, M Rava2, C Sarnowski3, L A M Smit14, S Temam2, R Varraso2, L Vignoud4, M Lathrop15, I Pin4, F Demenais3, F Kauffmann2, V Siroux4. 1. Inserm, UMR946, 75010 Paris, France; Université Paris Diderot, Sorbonne Paris Cité, institut universitaire d'hématologie, 75007 Paris, France. Electronic address: emmanuelle.bouzigon@inserm.fr. 2. Inserm, centre for research in epidemiology and population health (CESP), U1018, respiratory and environmental epidemiology team, 94807 Villejuif, France; Université Paris-Sud, UMRS 1018, 94807 Villejuif, France. 3. Inserm, UMR946, 75010 Paris, France; Université Paris Diderot, Sorbonne Paris Cité, institut universitaire d'hématologie, 75007 Paris, France. 4. Université Grenoble Alpes, IAB, team of environmental epidemiology applied to reproduction and respiratory health, 38000 Grenoble, France; Inserm, IAB, team of environmental epidemiology applied to reproduction and respiratory health, 38000 Grenoble, France; CHU de Grenoble, IAB, team of environmental epidemiology applied to reproduction and respiratory health, 38000 Grenoble, France. 5. Inserm, centre for research in epidemiology and population health (CESP), U1018, respiratory and environmental epidemiology team, 94807 Villejuif, France; Université Paris-Sud, UMRS 1018, 94807 Villejuif, France; CHU Arnaud-de-Villeneuve, 34000 Montpellier, France. 6. Université Grenoble Alpes, IAB, team of environmental epidemiology applied to reproduction and respiratory health, 38000 Grenoble, France; Inserm, IAB, team of environmental epidemiology applied to reproduction and respiratory health, 38000 Grenoble, France; CHU de Grenoble, IAB, team of environmental epidemiology applied to reproduction and respiratory health, 38000 Grenoble, France; Pôle de pharmacie, CHU de Grenoble, 38000 Grenoble, France; Inserm, U1055, 38000 Grenoble, France. 7. AP-HP, université Paris Descartes, Sorbonne Paris-Cité, 75005 Paris, France. 8. CHU, 69000 Lyon, France. 9. Inserm, centre for research in epidemiology and population health (CESP), U1018, respiratory and environmental epidemiology team, 94807 Villejuif, France; Université Paris-Sud, UMRS 1018, 94807 Villejuif, France; CREAL, centre for research in environmental epidemiology, Barcelone, Espagne. 10. Centre de l'asthme et des allergies, hôpital Trousseau, AP-HP, UMPC Paris 6, 75012 Paris, France. 11. Université Lille Nord de France, 59000 Lille, France; CHU, 59000 Lille, France. 12. Clinique universitaire de pneumologie, pôle de cancérologie, médecine aiguë et communautaire, CHU de Grenoble, 38000 Grenoble, France; Inserm, U1055, 38000 Grenoble, France; Université Grenoble Alpes, 38000 Grenoble, France. 13. Inserm, centre for research in epidemiology and population health (CESP), U1018, respiratory and environmental epidemiology team, 94807 Villejuif, France; Université Paris-Sud, UMRS 1018, 94807 Villejuif, France; PRP-HOM, SRBE, LEPID, institut de radioprotection et de sûreté nucléaire (IRSN), 92260 Fontenay-aux-Roses, France. 14. Division of environmental epidemiology, institute for risk assessment sciences (IRAS), Utrecht, Pays-Bas. 15. McGill university and génome Québec innovation centre, Montréal, Canada.
Abstract
INTRODUCTION AND METHODS: The EGEA study (epidemiological study on the genetics and environment of asthma, bronchial hyperresponsiveness and atopy), which combines a case-control and a family-based study of asthma case (n=2120 subjects) with three surveys over 20 years, aims to identify environmental and genetic factors associated with asthma and asthma-related phenotypes. We summarize the results of the phenotypic characterization and the investigation of environmental and genetic factors of asthma and asthma-related phenotypes obtained since 2007 in the EGEA study (42 articles). RESULTS: Both epidemiological and genetic results confirm the heterogeneity of asthma. These results strengthen the role of the age of disease onset, the allergic status and the level of disease activity in the identification of the different phenotypes of asthma. The deleterious role of active smoking, exposure to air pollution, occupational asthmogenic agents and cleaning products on the prevalence and/or activity of asthma has been confirmed. Accounting for gene-environment interactions allowed the identification of new genetic factors underlying asthma and asthma-related traits and better understanding of their mode of action. CONCLUSION: The EGEA study is contributing to the advances in respiratory research at the international level. The new phenotypic, environmental and biological data available in EGEA study will help characterizing the long-term evolution of asthma and the factors associated to this evolution.
INTRODUCTION AND METHODS: The EGEA study (epidemiological study on the genetics and environment of asthma, bronchial hyperresponsiveness and atopy), which combines a case-control and a family-based study of asthma case (n=2120 subjects) with three surveys over 20 years, aims to identify environmental and genetic factors associated with asthma and asthma-related phenotypes. We summarize the results of the phenotypic characterization and the investigation of environmental and genetic factors of asthma and asthma-related phenotypes obtained since 2007 in the EGEA study (42 articles). RESULTS: Both epidemiological and genetic results confirm the heterogeneity of asthma. These results strengthen the role of the age of disease onset, the allergic status and the level of disease activity in the identification of the different phenotypes of asthma. The deleterious role of active smoking, exposure to air pollution, occupational asthmogenic agents and cleaning products on the prevalence and/or activity of asthma has been confirmed. Accounting for gene-environment interactions allowed the identification of new genetic factors underlying asthma and asthma-related traits and better understanding of their mode of action. CONCLUSION: The EGEA study is contributing to the advances in respiratory research at the international level. The new phenotypic, environmental and biological data available in EGEA study will help characterizing the long-term evolution of asthma and the factors associated to this evolution.
Authors: Enrique Ambrocio-Ortiz; Gustavo Galicia-Negrete; Gloria Pérez-Rubio; Areli J Escobar-Morales; Edgar Abarca-Rojano; Alma D Del Angel-Pablo; Manuel D J Castillejos-López; Ramcés Falfán-Valencia Journal: Diagnostics (Basel) Date: 2020-04-30
Authors: Badr R Al-Ghamdi; Emad A Koshak; Fakhreldin M Omer; Nabil J Awadalla; Ahmed A Mahfouz; Hussein M Ageely Journal: Int J Environ Res Public Health Date: 2019-07-12 Impact factor: 3.390