| Literature DB >> 25794938 |
Tengfei Zheng1, Elizabeth M Nolan2.
Abstract
The syntheses of five ciprofloxacin-modified (acyloxyl)alkyl esters and two siderophore-ciprofloxacin conjugates based on enterobactin that harbor such hydrolyzable linkages are reported. The hydrolytic stabilities of ciprofloxacin-modified (acyloxy)alkyl esters, evaluated at pH 7.5 and 30°C, vary by >370-fold depending on the substituents in the vicinity of the ester linkage.Entities:
Keywords: Antibiotic delivery; Linker stability; Siderophore
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Year: 2015 PMID： 25794938 DOI： 10.1016/j.bmcl.2015.02.034
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823