| Literature DB >> 25794435 |
Ruth Birner-Gruenberger1, Rolf Breinbauer2.
Abstract
Posttranslational modifications (PTMs) control protein function, but established peptide-based proteomic methods often fail to provide a comprehensive view of PTMs. In this issue of Chemistry & Biology, Gersch et al. describe an efficient combination of chromatographic separation and top-down mass spectrometry that together with an intuitive visualization tool allowed them to screen the proteasome for PTMs and covalently binding inhibitors.Entities:
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Year: 2015 PMID： 25794435 DOI： 10.1016/j.chembiol.2015.03.003
Source DB: PubMed Journal: Chem Biol ISSN： 1074-5521