John Dingley1, Xun Liu, Hannah Gill, Elisa Smit, Hemmen Sabir, James Tooley, Ela Chakkarapani, David Windsor, Marianne Thoresen. 1. From the *College of Medicine, Swansea University, Wales, United Kingdom; †Neonatal Neuroscience, School of Clinical Science, University of Bristol, Bristol, United Kingdom; ‡Neonatal Intensive Care Unit and §Anaesthetic Department, University Hospital Bristol, Bristol, United Kingdom; and the ∥Department of Physiology, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
Abstract
BACKGROUND: Therapeutic hypothermia is the standard of care after perinatal asphyxia. Preclinical studies show 50% xenon improves outcome, if started early. METHODS: During a 32-patient study randomized between hypothermia only and hypothermia with xenon, 5 neonates were given xenon during retrieval using a closed-circuit incubator-mounted system. RESULTS: Without xenon availability during retrieval, 50% of eligible infants exceeded the 5-hour treatment window. With the transportable system, 100% were recruited. Xenon delivery lasted 55 to 120 minutes, using 174 mL/h (117.5-193.2) (median [interquartile range]), after circuit priming (1300 mL). CONCLUSIONS: Xenon delivery during ambulance retrieval was feasible, reduced starting delays, and used very little gas.
RCT Entities:
BACKGROUND: Therapeutic hypothermia is the standard of care after perinatal asphyxia. Preclinical studies show 50% xenon improves outcome, if started early. METHODS: During a 32-patient study randomized between hypothermia only and hypothermia with xenon, 5 neonates were given xenon during retrieval using a closed-circuit incubator-mounted system. RESULTS: Without xenon availability during retrieval, 50% of eligible infants exceeded the 5-hour treatment window. With the transportable system, 100% were recruited. Xenon delivery lasted 55 to 120 minutes, using 174 mL/h (117.5-193.2) (median [interquartile range]), after circuit priming (1300 mL). CONCLUSIONS:Xenon delivery during ambulance retrieval was feasible, reduced starting delays, and used very little gas.
Authors: Denis Azzopardi; Nicola J Robertson; Alan Bainbridge; Ernest Cady; Geoffrey Charles-Edwards; Aniko Deierl; Gianlorenzo Fagiolo; Nicholas P Franks; James Griffiths; Joseph Hajnal; Edmund Juszczak; Basil Kapetanakis; Louise Linsell; Mervyn Maze; Omar Omar; Brenda Strohm; Nora Tusor; A David Edwards Journal: Lancet Neurol Date: 2015-12-19 Impact factor: 44.182
Authors: John Dingley; Satomi Okano; Richard Lee-Kelland; Emma Scull-Brown; Marianne Thoresen; Ela Chakkarapani Journal: PLoS One Date: 2020-01-21 Impact factor: 3.240