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Literature DB >> 25792731

ADAMTS13, lucky to have a hydrophobic pocket.

Abstract

In this issue of Blood, de Groot et al identify a hydrophobic pocket in the Cys-rich domain of ADAMTS13 that appears to interact with the hydrophobic pocket in the central A2 domain of von Willebrand factor (VWF) for its proteolysis.

Entities: Chemical Gene

Mesh：

Substances：

Year: 2015 PMID： 25792731 PMCID： PMC4366622 DOI： 10.1182/blood-2015-01-621235

Source DB: PubMed Journal: Blood ISSN： 0006-4971 Impact factor: 22.113

11 in total

1. The proximal carboxyl-terminal domains of ADAMTS13 determine substrate specificity and are all required for cleavage of von Willebrand factor.

Authors: Jihui Ai; Paula Smith; Shuwei Wang; Ping Zhang; X Long Zheng
Journal: J Biol Chem Date: 2005-06-23 Impact factor: 5.157

2. Allosteric activation of ADAMTS13 by von Willebrand factor.

Authors: Joshua Muia; Jian Zhu; Garima Gupta; Sandra L Haberichter; Kenneth D Friedman; Hendrik B Feys; Louis Deforche; Karen Vanhoorelbeke; Lisa A Westfield; Robyn Roth; Niraj Harish Tolia; John E Heuser; J Evan Sadler
Journal: Proc Natl Acad Sci U S A Date: 2014-12-15 Impact factor: 11.205

3. Crystal structures of the noncatalytic domains of ADAMTS13 reveal multiple discontinuous exosites for von Willebrand factor.

Authors: Masashi Akiyama; Soichi Takeda; Koichi Kokame; Junichi Takagi; Toshiyuki Miyata
Journal: Proc Natl Acad Sci U S A Date: 2009-10-30 Impact factor: 11.205

Review 4. ADAMTS13 and von Willebrand factor in thrombotic thrombocytopenic purpura.

Authors: X Long Zheng
Journal: Annu Rev Med Date: 2015 Impact factor: 13.739

5. Essential domains of a disintegrin and metalloprotease with thrombospondin type 1 repeats-13 metalloprotease required for modulation of arterial thrombosis.

Authors: Juan Xiao; Sheng-Yu Jin; Jing Xue; Nicoletta Sorvillo; Jan Voorberg; X Long Zheng
Journal: Arterioscler Thromb Vasc Biol Date: 2011-07-28 Impact factor: 8.311

6. Conformational activation of ADAMTS13.

Authors: Kieron South; Brenda M Luken; James T B Crawley; Rebecca Phillips; Mari Thomas; Richard F Collins; Louis Deforche; Karen Vanhoorelbeke; David A Lane
Journal: Proc Natl Acad Sci U S A Date: 2014-12-15 Impact factor: 11.205

7. Essential role of the disintegrin-like domain in ADAMTS13 function.

Authors: Rens de Groot; Ajoy Bardhan; Nalisha Ramroop; David A Lane; James T B Crawley
Journal: Blood Date: 2009-02-20 Impact factor: 22.113

8. Amino acid residues Arg(659), Arg(660), and Tyr(661) in the spacer domain of ADAMTS13 are critical for cleavage of von Willebrand factor.

Authors: Sheng-Yu Jin; Christopher G Skipwith; X Long Zheng
Journal: Blood Date: 2010-01-14 Impact factor: 22.113

9. The role of the ADAMTS13 cysteine-rich domain in VWF binding and proteolysis.

Authors: Rens de Groot; David A Lane; James T B Crawley
Journal: Blood Date: 2015-01-06 Impact factor: 22.113

Review 10. VWF excess and ADAMTS13 deficiency: a unifying pathomechanism linking inflammation to thrombosis in DIC, malaria, and TTP.

Authors: Michael Schwameis; Christian Schörgenhofer; Alice Assinger; Margarete M Steiner; Bernd Jilma
Journal: Thromb Haemost Date: 2014-12-11 Impact factor: 5.249

2 in total

1. Prediction of spacer-α6 complex: a novel insight into binding of ADAMTS13 with A2 domain of von Willebrand factor under forces.

Authors: Xiang Fang; Jiangguo Lin; Ying Fang; Jianhua Wu
Journal: Sci Rep Date: 2018-04-10 Impact factor: 4.379

2. AFM Imaging Reveals Multiple Conformational States of ADAMTS13.

Authors: Shanshan Yu; Wang Liu; Jinhua Fang; Xiaozhong Shi; Jianhua Wu; Ying Fang; Jiangguo Lin
Journal: J Biol Eng Date: 2019-01-22 Impact factor: 4.355

2 in total