Angela Lucariello1, Elisabetta Trabucco2, Olga Boccia2, Angelica Perna3, Carmine Sellitto3, Maria A Castaldi2, Maria De Falco4, Antonio De Luca3, Luigi Cobellis2. 1. Department of Mental and Physical Health and Preventive Medicine, Section of Human Anatomy, Second University of Naples, Naples, Italy angela.lucariello@gmail.com. 2. Department of Gynaecology, Obstetric and Reproductive Science, Second University of Studies of Naples, Naples, Italy. 3. Department of Mental and Physical Health and Preventive Medicine, Section of Human Anatomy, Second University of Naples, Naples, Italy. 4. Department of Biology, Section of Evolutionary and Comparative Anatomy, University Federico II of Naples, Naples, Italy National Institute of Biostructures and Biosystems (INBB), Rome, Italy.
Abstract
BACKGROUND: During the woman's fertile period, the non-pregnant uterus is subject to constant cyclic changes. The complex mechanisms that control the balance among proliferation, differentiation, cell death and the structural remodeling of the extracellular matrix can contribute to the benign or malignant endometrial pathological state. The small leucine-rich proteoglycans (SLRPs) are important components of cell surface and extracellular matrices. MATERIALS AND METHODS: Using immunohistochemistry, we showed that the distribution patterns of SLRPs were completely modified in the pathological compared to normal endometrium. RESULTS: The expression of SLRPs was low/absent in all endometrial pathologies examined compared to normal endometrium. We observed an increase of lumican from proliferative to secretory phase of the endometrium and a decrease of fibromodulin, biglycan and decorin. In menopause endometrial tissue, the level of expression of fibromodulin, biglycan, decorin and lumican dramatically decreased. CONCLUSION: The results revealed the prominence and importance of proteoglycans in the tissue architecture and extracellular matrix organization.
BACKGROUND: During the woman's fertile period, the non-pregnant uterus is subject to constant cyclic changes. The complex mechanisms that control the balance among proliferation, differentiation, cell death and the structural remodeling of the extracellular matrix can contribute to the benign or malignant endometrial pathological state. The small leucine-rich proteoglycans (SLRPs) are important components of cell surface and extracellular matrices. MATERIALS AND METHODS: Using immunohistochemistry, we showed that the distribution patterns of SLRPs were completely modified in the pathological compared to normal endometrium. RESULTS: The expression of SLRPs was low/absent in all endometrial pathologies examined compared to normal endometrium. We observed an increase of lumican from proliferative to secretory phase of the endometrium and a decrease of fibromodulin, biglycan and decorin. In menopause endometrial tissue, the level of expression of fibromodulin, biglycan, decorin and lumican dramatically decreased. CONCLUSION: The results revealed the prominence and importance of proteoglycans in the tissue architecture and extracellular matrix organization.
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