Leyla Kilic1, Ibrahim Yildiz2, Fatma Karagoz Sen2, Mustafa Genco Erdem3, Murat Serilmez4, Serkan Keskin2, Rumeysa Ciftci2, Senem Karabulut2, Cetin Ordu5, Derya Duranyildiz4, Faruk Tas2. 1. Medical Oncology Department, Firat University Hospital, Elazig, Turkey. 2. Medical Oncology Department, Institute of Oncology, Istanbul University, Capa, Istanbul, Turkey. 3. Agri Hamur State Hospital, Internal Medicine Clinic, Hamur, Agri, Turkey. 4. Biochemistry Department, Institute of Oncology, Istanbul University, Capa, Istanbul, Turkey. 5. Medical Oncology Department, Bedii Gorbon Oncology Center, Avrupa Florence Nightingale Hospital, Sisli, Istanbul, Turkey.
Abstract
BACKGROUND: The aim of this study is to evaluate the correlation of coagulation tests with various clinicopathological variables and tumor markers among colorectal cancer (CRC) patients. MATERIALS AND METHODS: Ninety-four CRC patients were included for evaluation of clinicopathological factors, coagulation assays and tumor marker levels. RESULTS: Metastatic disease was related with elevated INR (p= 0.03). Stage III patients had higher D-dimer values compared with stage II patients (p= 0.03). Correlation of tumor markers indicated a tendency towards elevated D-dimer levels for CEA values higher than median (p= 0.01). High CA 19-9 levels were also associated with higher INR (p= 0.007). Elderly age, distant metastasis, high CEA, CA-19-9 and LDH levels were associated with poorer overall-survival. CEA level was the only independent prognostic factor in multivariate analysis. CONCLUSIONS: Coagulation assays can be utilized as predictors of disease extent in CRC. Elevated D-dimer and INR values may indicate higher disease stage. Correlation of D-dimer levels with CEA supports their value for assessing tumor burden.
BACKGROUND: The aim of this study is to evaluate the correlation of coagulation tests with various clinicopathological variables and tumor markers among colorectal cancer (CRC) patients. MATERIALS AND METHODS: Ninety-four CRC patients were included for evaluation of clinicopathological factors, coagulation assays and tumor marker levels. RESULTS:Metastatic disease was related with elevated INR (p= 0.03). Stage III patients had higher D-dimer values compared with stage II patients (p= 0.03). Correlation of tumor markers indicated a tendency towards elevated D-dimer levels for CEA values higher than median (p= 0.01). High CA 19-9 levels were also associated with higher INR (p= 0.007). Elderly age, distant metastasis, high CEA, CA-19-9 and LDH levels were associated with poorer overall-survival. CEA level was the only independent prognostic factor in multivariate analysis. CONCLUSIONS: Coagulation assays can be utilized as predictors of disease extent in CRC. Elevated D-dimer and INR values may indicate higher disease stage. Correlation of D-dimer levels with CEA supports their value for assessing tumor burden.
Entities:
Keywords:
CA 19-9; CEA; D-dimer; Tumor marker; coagulation; colon cancer