| Literature DB >> 2579236 |
B Loev, J H Musser, R E Brown, H Jones, R Kahen, F C Huang, A Khandwala, P Sonnino-Goldman, M J Leibowitz.
Abstract
A series of new 1,4-dihydro-1,2,4-triazolo[4,3-]quinoxaline-1,4-diones has been prepared. These compounds were tested as inhibitors of antigen-induced release of histamine (AIR) in vitro from rat peritoneal mast cells (RMC) and as inhibitors of IgE-mediated rat passive cutaneous anaphylaxis (PCA). Most of this new class of antiallergic agents showed good activity in the RMC and PCA tests. The most potent compound, 2-acetyl-7-chloro-5-n-propyl-1,2,4-triazolo[4,3-a]quinoxaline-1,4-dione (1x), with an I50 value of 0.1 microM, is 30 times more potent than disodium cromoglycate (DSCG) in the RMC assay.Entities:
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Year: 1985 PMID： 2579236 DOI： 10.1021/jm00381a016
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446