Salah E Altarabsheh1, Salil V Deo2, Abeer M Rababa'h3, Ju Yong Lim4, Yang Hyun Cho5, Vikas Sharma6, Sung Ho Jung4, Euisoo Shin4, Alan H Markowitz2, Soon J Park2. 1. Department of Cardiovascular Surgery, Queen Alia Heart Institute, Amman, Jordan. Electronic address: salah936@yahoo.com. 2. Department of Cardiovascular Surgery, University Hospitals, Case Medical Center, Case Western Reserve University, Cleveland, Ohio. 3. Department of Clinical Pharmacy, Jordan University of Science and Technology, Irbid, Jordan. 4. Department of Cardiovascular Surgery, Asan Medical Center, Seoul, South Korea. 5. Department of Cardiovascular Surgery, Samsung Hospital, Sungkyunkwan University of Medical Sciences, Seoul, South Korea. 6. Department of General Surgery, Wellspan York Hospital, York, Pennsylvania.
Abstract
BACKGROUND: Data comparing results of off-pump and conventional operations in octogenarians is very limited. Thus we chose to compare early adverse events between off-pump coronary artery bypass grafting (OPCABG) and on-pump CABG (ONCABG) in patients older than 80 years. METHODS: Systematic review of multiple databases was performed to obtain original studies fulfilling search criteria. End points--early mortality, stroke, respiratory failure, atrial fibrillation, and myocardial infarction--were compared between these cohorts. A random-effects weighted analysis was performed using the trim-fill adjustment when necessary. Results are presented as risk ratios (RRs) with 95% confidence intervals (CIs); p < 0.05 is considered statistically significant. RESULTS: Sixteen retrospective studies (9,744 ONCABG and 8,566 OPCABG patients) were included in the systematic review. OPCAGB patients received significantly fewer grafts (2.54 ± 0.16) compared with ONCABG patients (3.22 ± 0.41). Early mortality was comparable at 4.6% and 5.2% in the OPCABG and ONCABG cohorts, respectively (risk ratio [RR], 0.91; 95% CI, 0.64-1.28; p = 0.598). Stroke rates were higher in the ONCABG cohort (RR, 0.65; 95% CI, 0.49- 0.87; p < 0.01). Respiratory failure was higher with ONCABG (RR, 0.74; 95% CI, 0.57-0.97; p = 0.03). New-onset renal failure (p = 0.99), atrial fibrillation (p = 0.27), and myocardial infarction (p = 0.99) were comparable. CONCLUSIONS: Coronary artery bypass in octogenarians can be performed safely with low early mortality. Although off-pump operations reduce the risk of early stroke, all other adverse events are comparable in on- and off-pump coronary artery bypass operations. Data regarding late mortality is at present limited; however, both on- and off-pump procedures appear to produce comparable survival.
BACKGROUND: Data comparing results of off-pump and conventional operations in octogenarians is very limited. Thus we chose to compare early adverse events between off-pump coronary artery bypass grafting (OPCABG) and on-pump CABG (ONCABG) in patients older than 80 years. METHODS: Systematic review of multiple databases was performed to obtain original studies fulfilling search criteria. End points--early mortality, stroke, respiratory failure, atrial fibrillation, and myocardial infarction--were compared between these cohorts. A random-effects weighted analysis was performed using the trim-fill adjustment when necessary. Results are presented as risk ratios (RRs) with 95% confidence intervals (CIs); p < 0.05 is considered statistically significant. RESULTS: Sixteen retrospective studies (9,744 ONCABG and 8,566 OPCABG patients) were included in the systematic review. OPCAGB patients received significantly fewer grafts (2.54 ± 0.16) compared with ONCABG patients (3.22 ± 0.41). Early mortality was comparable at 4.6% and 5.2% in the OPCABG and ONCABG cohorts, respectively (risk ratio [RR], 0.91; 95% CI, 0.64-1.28; p = 0.598). Stroke rates were higher in the ONCABG cohort (RR, 0.65; 95% CI, 0.49- 0.87; p < 0.01). Respiratory failure was higher with ONCABG (RR, 0.74; 95% CI, 0.57-0.97; p = 0.03). New-onset renal failure (p = 0.99), atrial fibrillation (p = 0.27), and myocardial infarction (p = 0.99) were comparable. CONCLUSIONS: Coronary artery bypass in octogenarians can be performed safely with low early mortality. Although off-pump operations reduce the risk of early stroke, all other adverse events are comparable in on- and off-pump coronary artery bypass operations. Data regarding late mortality is at present limited; however, both on- and off-pump procedures appear to produce comparable survival.
Authors: Umberto Benedetto; Gianni D Angelini; Massimo Caputo; Dmitriy N Feldman; Luke K Kim; Christopher Lau; Antonino Di Franco; Leonard N Girardi; Mario Gaudino Journal: J Thorac Dis Date: 2017-12 Impact factor: 2.895
Authors: Salil V Deo; Yakov Elgudin; A Laurie W Shroyer; Salah Altarabsheh; Vikas Sharma; Joseph Rubelowsky; Lorraine Cornwell; Piroze Davierwala; Danny Chu; Brian Cmolik Journal: J Am Heart Assoc Date: 2022-03-01 Impact factor: 6.106