BACKGROUND/AIMS: Endoplasmic reticulum (ER) stress is one of the intrinsic apoptosis pathways, and cardiac apoptosis can occur in cardiovascular diseases, such as hypertension. However, the mechanisms by which ER stress leads to apoptosis remain enigmatic, particularly in the progression from cardiac hypertrophy to diastolic heart failure due to hypertension. METHODS: We used spontaneously hypertensive rats (SHRs) to investigate possible signalling pathways for ER stress. RESULTS: We found that cardiac protein and mRNA levels of glucoseregulated protein 78 were up-regulated. In addition, the CHOP- and caspase-12-dependent pathways, but not that of JNK, were activated in the SHR rats. CONCLUSIONS: These results suggest that ER stress can contribute to myocardial apoptosis during hypertensive disease.
BACKGROUND/AIMS: Endoplasmic reticulum (ER) stress is one of the intrinsic apoptosis pathways, and cardiac apoptosis can occur in cardiovascular diseases, such as hypertension. However, the mechanisms by which ER stress leads to apoptosis remain enigmatic, particularly in the progression from cardiac hypertrophy to diastolic heart failure due to hypertension. METHODS: We used spontaneously hypertensiverats (SHRs) to investigate possible signalling pathways for ER stress. RESULTS: We found that cardiac protein and mRNA levels of glucoseregulated protein 78 were up-regulated. In addition, the CHOP- and caspase-12-dependent pathways, but not that of JNK, were activated in the SHR rats. CONCLUSIONS: These results suggest that ER stress can contribute to myocardial apoptosis during hypertensive disease.
Authors: Oliul Islam; Prashanth Patil; Sumanta K Goswami; Rema Razdan; Mohammed N Inamdar; Mohammed Rizwan; Jubin Mathew; Bora Inceoglu; Kin S Stephen Lee; Sung H Hwang; Bruce D Hammock Journal: Cardiovasc Ther Date: 2017-06 Impact factor: 3.023
Authors: Li Jin; Zhe Hao Piao; Chun Ping Liu; Simei Sun; Bin Liu; Gwi Ran Kim; Sin Young Choi; Yuhee Ryu; Hae Jin Kee; Myung Ho Jeong Journal: J Cell Mol Med Date: 2017-12-20 Impact factor: 5.310
Authors: Jie Yang; Junli Hao; Yapeng Lin; Yijia Guo; Ke Liao; Min Yang; Hang Cheng; Ming Yang; Kejie Chen Journal: Front Genet Date: 2022-03-14 Impact factor: 4.599
Authors: Michał Biernacki; Wojciech Łuczaj; Iwona Jarocka-Karpowicz; Ewa Ambrożewicz; Marek Toczek; Elżbieta Skrzydlewska Journal: Molecules Date: 2018-09-14 Impact factor: 4.411