Literature DB >> 25789813

Genetic testing for age-related macular degeneration: not indicated now.

Edwin M Stone1.   

Abstract

Age-related macular degeneration is a very common condition that is caused by a complex interplay of genetic and environmental factors. It is likely that, in the future, genetic testing will allow physicians to achieve better clinical outcomes by administering specific treatments to patients based on their genotypes. However, improved outcomes for genotyped patients have not yet been demonstrated in a prospective clinical trial, and as a result, the costs and risks of routine genetic testing currently outweigh the benefits for patients with age-related macular degeneration.

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Year:  2015        PMID： 25789813     DOI： 10.1001/jamaophthalmol.2015.0369

Source DB:  PubMed          Journal:  JAMA Ophthalmol        ISSN： 2168-6165            Impact factor:   7.389


  13 in total

Review 1.  Risk factors and biomarkers of age-related macular degeneration.

Authors:  Nathan G Lambert; Hanan ElShelmani; Malkit K Singh; Fiona C Mansergh; Michael A Wride; Maximilian Padilla; David Keegan; Ruth E Hogg; Balamurali K Ambati
Journal:  Prog Retin Eye Res       Date:  2016-05-06       Impact factor: 21.198

Review 2.  Genetics and genetic testing for age-related macular degeneration.

Authors:  A Warwick; A Lotery
Journal:  Eye (Lond)       Date:  2017-11-10       Impact factor: 3.775

3.  No CFH or ARMS2 Interaction with Omega-3 Fatty Acids, Low versus High Zinc, or β-Carotene versus Lutein and Zeaxanthin on Progression of Age-Related Macular Degeneration in the Age-Related Eye Disease Study 2: Age-Related Eye Disease Study 2 Report No. 18.

Authors:  Freekje van Asten; Chi-Yang Chiu; Elvira Agrón; Traci E Clemons; Rinki Ratnapriya; Anand Swaroop; Michael L Klein; Ruzong Fan; Emily Y Chew
Journal:  Ophthalmology       Date:  2019-06-12       Impact factor: 12.079

4.  Nutrition, Genes, and Age-Related Macular Degeneration: What Have We Learned from the Trials?

Authors:  Emily Y Chew
Journal:  Ophthalmologica       Date:  2017-05-06       Impact factor: 3.250

5.  Age-related Macular Degeneration: Nutrition, Genes and Deep Learning-The LXXVI Edward Jackson Memorial Lecture.

Authors:  Emily Y Chew
Journal:  Am J Ophthalmol       Date:  2020-06-20       Impact factor: 5.258

6.  The Royal College of Ophthalmologists Commissioning guidelines on age macular degeneration: executive summary.

Authors:  Shruti Chandra; Martin McKibbin; Sajjad Mahmood; Louise Downey; Beth Barnes; Sobha Sivaprasad
Journal:  Eye (Lond)       Date:  2022-05-27       Impact factor: 4.456

Review 7.  Pharmacogenetics and nutritional supplementation in age-related macular degeneration.

Authors:  Blake M Hampton; Jaclyn L Kovach; Stephen G Schwartz
Journal:  Clin Ophthalmol       Date:  2015-05-15

8.  Ethical Considerations for the Return of Incidental Findings in Ophthalmic Genomic Research.

Authors:  Emmanuelle Souzeau; Kathryn P Burdon; David A Mackey; Alex W Hewitt; Ravi Savarirayan; Margaret Otlowski; Jamie E Craig
Journal:  Transl Vis Sci Technol       Date:  2016-02-09       Impact factor: 3.283

9.  A Validated Phenotyping Algorithm for Genetic Association Studies in Age-related Macular Degeneration.

Authors:  Joseph M Simonett; Mahsa A Sohrab; Jennifer Pacheco; Loren L Armstrong; Margarita Rzhetskaya; Maureen Smith; M Geoffrey Hayes; Amani A Fawzi
Journal:  Sci Rep       Date:  2015-08-10       Impact factor: 4.379

Review 10.  Genetics and age-related macular degeneration: a practical review for the clinician.

Authors:  Stephen G Schwartz; Blake M Hampton; Jaclyn L Kovach; Milam A Brantley
Journal:  Clin Ophthalmol       Date:  2016-07-04
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