CO2 angiography for peripheral arterial imaging: the good, bad, and ugly.

This article demonstrates that carbon dioxide (CO2) based angiography can be performed in patients at risk of acute kidney injury (AKI) with a resulting rate of AKI of ∼5%. The study also demonstrates a high rate of complications from CO2 angiography--ranging from pain to death. Future research will need to focus on clarifying the role of CO2 angiography given the safety profile noted in the literature.