To the Editor,We thank the authors for their valuable comments on our study entitled, “Breast arterial calcifications (BAC) and carotid intima-media thickness and hemodynamics: Is there any association?” published in Anatolian J Cardiol 2014; 14: 378-82 (1).First, patients using diuretics, hormone replacement therapy (HRT), and steroids and those under treatment for osteoporosis were excluded in our study.In our study, the average postmenopausal period was found to be 13.38±1.06 and 10.2±1.01 years in the BAC (+) and BAC (-) groups, respectively. Since, in our study, a significant relation was found between age and BAC. This result was concordant with previous literature findings. The differences between the BAC (+) and (-) groups with regard to postmenopausal period were significant after excluding the effects of age. However, no significant correlation was found between postmenopausal period and the presence of BAC. This led us to infer that the real cause of BAC in patients with a longer postmenopausal period was the advancing age of the patient, not the length of the post-menopausal period.The results of observational studies, which last up to 10 years, suggest that postmenopausal HRT protects women from cardiovascular events and decreases the risk of coronary artery disease by 35%-50%. However, the data of observational studies have not been confirmed by recent randomized studies; so, this subject is still controversial in the literature (2). As a result of our study, we think that BAC is not directly associated with the atherosclerotic process. While the evidence of the effect of HRT on atherosclerosis is controversial, we approach the theory that HRT decreases BAC with suspicion, as we do not consider it an atherosclerotic process.