Literature DB >> 25788107

Metabolism of classical cannabinoids and the synthetic cannabinoid JWH-018.

M K Su1, K A Seely2, J H Moran2,3, R S Hoffman1.   

Abstract

Although the putative pharmacological targets of synthetic cannabinoids (SCBs) abused in "K2" and "Spice" are similar to Δ(9) -tetrahydrocannabinol (Δ(9) -THC), it remains unclear why SCB toxicity is similar yet different from marijuana. There are obvious potency and efficacy differences, but also important metabolic differences that help explain the unique adverse reactions associated with SCBs. This brief review discusses the limited research on the metabolism of the SCB JWH-018 and contrasts that with the metabolism of Δ(9) -THC.
© 2015 American Society for Clinical Pharmacology and Therapeutics.

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Year:  2015        PMID： 25788107     DOI： 10.1002/cpt.114

Source DB:  PubMed          Journal:  Clin Pharmacol Ther        ISSN： 0009-9236            Impact factor:   6.875


  8 in total

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Authors:  Mark Henry Alon; Margaret Olibrice Saint-Fleur
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4.  AM-2201 Inhibits Multiple Cytochrome P450 and Uridine 5'-Diphospho-Glucuronosyltransferase Enzyme Activities in Human Liver Microsomes.

Authors:  Ju-Hyun Kim; Soon-Sang Kwon; Tae Yeon Kong; Jae Chul Cheong; Hee Seung Kim; Moon Kyo In; Hye Suk Lee
Journal:  Molecules       Date:  2017-03-10       Impact factor: 4.411

5.  In Vitro Inhibitory Effects of Synthetic Cannabinoid EAM-2201 on Cytochrome P450 and UDP-Glucuronosyltransferase Enzyme Activities in Human Liver Microsomes.

Authors:  Tae Yeon Kong; Soon-Sang Kwon; Jae Chul Cheong; Hee Seung Kim; Jin Young Kim; Hye Suk Lee
Journal:  Molecules       Date:  2018-04-16       Impact factor: 4.411

6.  A Curious Case of Inhalation Fever Caused by Synthetic Cannabinoid.

Authors:  Thiru Chinnadurai; Srijan Shrestha; Raji Ayinla
Journal:  Am J Case Rep       Date:  2016-06-05

7.  Retrospective Chart Review of Synthetic Cannabinoid Intoxication with Toxicologic Analysis.

Authors:  Payal Sud; Miles Gordon; Laura Tortora; Matthew Stripp; Damon Borg; Adam Berman
Journal:  West J Emerg Med       Date:  2018-03-08

8.  An Investigation of the COMT Gene Val158Met Polymorphism in Patients Admitted to the Emergency Department Because of Synthetic Cannabinoid Use.

Authors:  Y Nennicioglu; H Kaya; S Eraybar; S Atmaca; O Gorukmez; E Armagan
Journal:  Balkan J Med Genet       Date:  2020-08-26       Impact factor: 0.519
  8 in total

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