OBJECTIVES: The aim of this study was to investigate the cytotoxic and antitumour effects of the essential oil from the leaves of Mentha x villosa (EOMV) and its main component (rotundifolone). METHODS: In-vitro cytotoxic activity of the EOMV and rotundifolone was determined on cultured tumour cells. In-vivo antitumour activity of the EOMV was assessed in sarcoma 180-bearing mice. KEY FINDINGS: The EOMV displayed cytotoxicity against human tumour cell lines, showing IC50 values in the range of 0.57-1.02 μg/ml in the HCT-116 and SF-295 cell lines, respectively. Rotundifolone showed weak cytotoxicity against HCT-116, SF-295 and OVCAR-8 cell lines (IC50 > 25.00 μg/ml). Tumour growth inhibition rates were 29.4-40.5% and 25.0-45.2% for the EOMV treatment by intraperitoneal (50-100 mg/kg/day) and oral (100-200 mg/kg/day) administration, respectively. The EOMV did not significantly affect body mass and macroscopy of the organs. CONCLUSIONS: The EOMV possesses significant antitumour activity with low systemic toxicity, possibly due to the synergistic action of its minor constituents.
OBJECTIVES: The aim of this study was to investigate the cytotoxic and antitumour effects of the essential oil from the leaves of Mentha x villosa (EOMV) and its main component (rotundifolone). METHODS: In-vitro cytotoxic activity of the EOMV and rotundifolone was determined on cultured tumour cells. In-vivo antitumour activity of the EOMV was assessed in sarcoma 180-bearing mice. KEY FINDINGS: The EOMV displayed cytotoxicity against humantumour cell lines, showing IC50 values in the range of 0.57-1.02 μg/ml in the HCT-116 and SF-295 cell lines, respectively. Rotundifolone showed weak cytotoxicity against HCT-116, SF-295 and OVCAR-8 cell lines (IC50 > 25.00 μg/ml). Tumour growth inhibition rates were 29.4-40.5% and 25.0-45.2% for the EOMV treatment by intraperitoneal (50-100 mg/kg/day) and oral (100-200 mg/kg/day) administration, respectively. The EOMV did not significantly affect body mass and macroscopy of the organs. CONCLUSIONS: The EOMV possesses significant antitumour activity with low systemic toxicity, possibly due to the synergistic action of its minor constituents.
Authors: Thiago José Matos-Rocha; Marília Gabriela dos Santos Cavalcanti; Dyana Leal Veras; Ana Paula Sampaio Feitosa; Gabriel Gazzoni Araújo Gonçalves; Nairomberg Cavalcanti Portela-Junior; Ana Silvia Suassuna Carneiro Lúcio; Anekécia Lauro da Silva; Rafael José Ribeiro Padilha; Márcia Ortiz Mayo Marques; José Maria Barbosa-Filho; Luiz Carlos Alves; Fábio André Brayner Journal: Rev Inst Med Trop Sao Paulo Date: 2016-02-23 Impact factor: 1.846
Authors: Ricardo G Amaral; Silvana V F Gomes; Luciana N Andrade; Sara A Dos Santos; Patrícia Severino; Ricardo L C de Albuquerque Júnior; Eliana B Souto; Geraldo C Brandão; Sandra L Santos; Jorge M David; Adriana A Carvalho Journal: Molecules Date: 2020-10-20 Impact factor: 4.411