Mohammad Khalesi1,2,3, David C Whiteman2,3, Cliff Rosendahl4,5, Richard Johns4, Timothy Hackett4,5, Alan Cameron4,5, Mary Waterhouse2, Robyn M Lucas6,7, Michael G Kimlin1,3, Rachel E Neale2,3. 1. Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD, Australia. 2. Department of Population Health, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia. 3. NHMRC Centre for Research Excellence in Sun and Health, Queensland University of Technology, Brisbane, QLD, Australia. 4. Skin Cancer College Australasia, Brisbane, QLD, Australia. 5. School of Medicine, The University of Queensland, Brisbane, QLD, Australia. 6. National Centre for Epidemiology and Population Health, The Australian National University, Canberra, ACT, Australia. 7. Telethon Kids Institute, University of Western Australia, Perth, WA, Australia.
Abstract
BACKGROUND: Basal cell carcinoma (BCC) is the most commonly diagnosed cancer in White populations. There are indications that risk factors for BCC may differ according to the anatomic site of the tumour but this is not well understood. PURPOSE: To compare phenotypic and environmental risk factors for BCCs arising on sun-protected sites with that of those on sun-exposed sites. METHODS: We conducted a case-case study in which people who had been diagnosed with incident BCC were recruited between February 2012 and September 2013 in Brisbane, Australia. RESULTS: Fair skin (OR: 4.50; 95% CI: 1.22, 16.59), having more than 15 lesions frozen/burnt off compared to less than 5 (OR: 5.68; 95% CI: 1.78, 18.08) and severe acne (OR: 5.25; 95% CI: 1.34, 20.56) were associated with increased risk of BCC on sun-protected sites. The presence of more than 5 nevi on the body was associated with decreased risk (OR: 0.28; 95% CI: 0.11, 0.71). CONCLUSIONS: BCCs on sun-protected sites arise as a result of excessive sun exposure, most likely combined with phenotypic susceptibility. The strong negative association with nevi also suggests that there are constitutional factors that underlie the propensity for BCCs to arise on these body sites.
BACKGROUND:Basal cell carcinoma (BCC) is the most commonly diagnosed cancer in White populations. There are indications that risk factors for BCC may differ according to the anatomic site of the tumour but this is not well understood. PURPOSE: To compare phenotypic and environmental risk factors for BCCs arising on sun-protected sites with that of those on sun-exposed sites. METHODS: We conducted a case-case study in which people who had been diagnosed with incident BCC were recruited between February 2012 and September 2013 in Brisbane, Australia. RESULTS: Fair skin (OR: 4.50; 95% CI: 1.22, 16.59), having more than 15 lesions frozen/burnt off compared to less than 5 (OR: 5.68; 95% CI: 1.78, 18.08) and severe acne (OR: 5.25; 95% CI: 1.34, 20.56) were associated with increased risk of BCC on sun-protected sites. The presence of more than 5 nevi on the body was associated with decreased risk (OR: 0.28; 95% CI: 0.11, 0.71). CONCLUSIONS: BCCs on sun-protected sites arise as a result of excessive sun exposure, most likely combined with phenotypic susceptibility. The strong negative association with nevi also suggests that there are constitutional factors that underlie the propensity for BCCs to arise on these body sites.
Authors: Christian Trummer; Marlene Pandis; Nicolas Verheyen; Martin R Grübler; Martin Gaksch; Barbara Obermayer-Pietsch; Andreas Tomaschitz; Thomas R Pieber; Stefan Pilz; Verena Schwetz Journal: Int J Environ Res Public Health Date: 2016-10-19 Impact factor: 3.390
Authors: Mark P Little; Terrence Lee; Michael G Kimlin; Martha S Linet; Elizabeth K Cahoon; Cari M Kitahara; Rui Zhang; Bruce H Alexander Journal: Cancer Epidemiol Biomarkers Prev Date: 2021-07-21 Impact factor: 4.090