| Literature DB >> 25787235 |
Weiguo Xu1, Jianxun Ding, Lingyu Li, Chunsheng Xiao, Xiuli Zhuang, Xuesi Chen.
Abstract
An acid-labile dextran-bortezomib conjugate (Dex-BTZ), i.e., a macromolecularized proteasome inhibitor, is synthesized by a boron esterification reaction. The prodrug exhibits intracellular acidity-accelerated BTZ release, and up-regulated inhibition efficacies toward hypoxic tumor in vitro and in vivo through both NF-κB- and ERS-mediated apoptosis signaling pathways.Entities:
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Year: 2015 PMID： 25787235 DOI： 10.1039/c5cc01371b
Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222