| Literature DB >> 25786169 |
Abstract
How the immune system is negatively affected by sepsis is not fully understood. In this issue of Immunity, Shalova et al. (2015) show that during human sepsis monocytes upregulate hypoxia-inducible factor-α (HIF1-α) activity and acquire an immunosuppressive phenotype while retaining anti-bacterial and wound-healing properties.Entities:
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Year: 2015 PMID： 25786169 DOI： 10.1016/j.immuni.2015.02.016
Source DB: PubMed Journal: Immunity ISSN： 1074-7613 Impact factor: 31.745