| Literature DB >> 25785947 |
Andrzej T Slominski1, Rüdiger Hardeland2, Russel J Reiter3.
Abstract
Silencing of BMAL1 and PER1 stimulates melanogenic activity of follicular and epidermal melanocytes, indicating a novel role for peripheral circadian clock processes in the regulation of melanin pigmentation. Linking the expression levels of BMAL1/PER1 with changes in melanogenesis opens exciting opportunities to study the role of the local molecular clock in modulation of melanocyte functions in the hair follicle and the epidermis with attendant effects on epidermal barrier functions in general.Entities:
Mesh:
Year: 2015 PMID: 25785947 PMCID: PMC5521957 DOI: 10.1038/jid.2014.553
Source DB: PubMed Journal: J Invest Dermatol ISSN: 0022-202X Impact factor: 8.551