Literature DB >> 25785946

The double life of connexin channels: single is a treat.

Roberto Bruzzone1.   

Abstract

Although several genetic diseases are caused by mutations in channels made by connexin family members, there has been little progress in the development and validation of therapeutic options. An in vitro study in this issue of JID suggests that an anti-malarial drug may be beneficial in keratitis-ichthyosis deafness, a severe conexin channel disease associated with potentially fatal recurrent infections.

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Year:  2015        PMID： 25785946     DOI： 10.1038/jid.2014.524

Source DB:  PubMed          Journal:  J Invest Dermatol        ISSN： 0022-202X            Impact factor:   8.551


  14 in total

Review 1.  Mechanisms linking connexin mutations to human diseases.

Authors:  John J Kelly; Jamie Simek; Dale W Laird
Journal:  Cell Tissue Res       Date:  2014-11-16       Impact factor: 5.249

2.  Transmission at the giant motor synapses of the crayfish.

Authors:  E J FURSHPAN; D D POTTER
Journal:  J Physiol       Date:  1959-03-03       Impact factor: 5.182

Review 3.  Plasma membrane channels formed by connexins: their regulation and functions.

Authors:  Juan C Saez; Viviana M Berthoud; Maria C Branes; Agustin D Martinez; Eric C Beyer
Journal:  Physiol Rev       Date:  2003-10       Impact factor: 37.312

Review 4.  Cell-cell communication beyond connexins: the pannexin channels.

Authors:  Michael T Barbe; Hannah Monyer; Roberto Bruzzone
Journal:  Physiology (Bethesda)       Date:  2006-04

5.  The effects of quinine and quinidine on isolated retinal horizontal cells.

Authors:  R P Malchow; H Qian; L M Haugh-Scheidt; H Ripps
Journal:  Biol Bull       Date:  1994-10       Impact factor: 1.818

6.  Pannexin 1 channels mediate 'find-me' signal release and membrane permeability during apoptosis.

Authors:  Faraaz B Chekeni; Michael R Elliott; Joanna K Sandilos; Scott F Walk; Jason M Kinchen; Eduardo R Lazarowski; Allison J Armstrong; Silvia Penuela; Dale W Laird; Guy S Salvesen; Brant E Isakson; Douglas A Bayliss; Kodi S Ravichandran
Journal:  Nature       Date:  2010-10-14       Impact factor: 49.962

Review 7.  Involvement of gap junction channels in the pathophysiology of migraine with aura.

Authors:  Denis Sarrouilhe; Catherine Dejean; Marc Mesnil
Journal:  Front Physiol       Date:  2014-02-25       Impact factor: 4.566

8.  Hexagonal array of subunits in intercellular junctions of the mouse heart and liver.

Authors:  J P Revel; M J Karnovsky
Journal:  J Cell Biol       Date:  1967-06       Impact factor: 10.539

Review 9.  Motifs in the permeation pathway of connexin channels mediate voltage and Ca (2+) sensing.

Authors:  Andrew L Harris; Jorge E Contreras
Journal:  Front Physiol       Date:  2014-03-31       Impact factor: 4.566

10.  Aberrant connexin26 hemichannels underlying keratitis-ichthyosis-deafness syndrome are potently inhibited by mefloquine.

Authors:  Noah A Levit; Caterina Sellitto; Hong-Zhan Wang; Leping Li; Miduturu Srinivas; Peter R Brink; Thomas W White
Journal:  J Invest Dermatol       Date:  2014-09-17       Impact factor: 8.551
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  1 in total

1.  Design and Characterization of a Human Monoclonal Antibody that Modulates Mutant Connexin 26 Hemichannels Implicated in Deafness and Skin Disorders.

Authors:  Liang Xu; Andrea Carrer; Francesco Zonta; Zhihu Qu; Peixiang Ma; Sheng Li; Federico Ceriani; Damiano Buratto; Giulia Crispino; Veronica Zorzi; Gaia Ziraldo; Francesca Bruno; Chiara Nardin; Chiara Peres; Flavia Mazzarda; Anna M Salvatore; Marcello Raspa; Ferdinando Scavizzi; Youjun Chu; Sichun Xie; Xuemei Yang; Jun Liao; Xiao Liu; Wei Wang; Shanshan Wang; Guang Yang; Richard A Lerner; Fabio Mammano
Journal:  Front Mol Neurosci       Date:  2017-09-22       Impact factor: 5.639
  1 in total

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