Yu Gong1, Kehong Feng, Ning Yan, Yong Xu, Chen-Wei Pan. 1. *MD †BSc ‡MSc §MD, PhD Department of Ophthalmology, Children's Hospital of Soochow University, Suzhou, China (YG, KF); and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, School of Public Health, Medical College of Soochow University, Suzhou, China (NY, YX, C-WP).
Abstract
PURPOSE: To evaluate the association between different amounts of alcohol consumption and the risk of age-related cataract. METHODS: We searched PubMed and Embase from their inception until May 2014 for case-control or cohort studies with data on alcohol consumption and age-related cataract. Heavy alcohol consumption was defined as more than two standard drinks per day, which is equal to a daily intake of 20 g of alcohol or 140 g per week. Moderate consumption was defined as less than 20 g of alcohol per day but more than never any. We performed separate meta-analyses for the associations of moderate or heavy alcohol consumption with age-related cataract under a random-effects model, respectively. RESULTS: Five case-control and five cohort studies were identified through comprehensive literature search. In the meta-analysis of 10 studies, the associations between moderate alcohol consumption and age-related cataract were marginally nonsignificant (pooled relative risk, 0.88; 95% confidence interval, 0.74 to 1.05; I = 82.1%), whereas heavy alcohol consumption was associated with an increased risk of age-related cataract (pooled relative risk, 1.26; 95% confidence interval, 1.06 to 1.50; I = 58.9%). The association between heavy alcohol consumption and cataract was stronger in case-control than in cohort studies. Adjusting for smoking as a potential confounder attenuated the association between heavy alcohol consumption and cataract. CONCLUSIONS: Heavy alcohol consumption significantly increased the risk of age-related cataract, whereas moderate consumption may be protective for this ocular condition. Clinically, information on a patient's alcohol drinking history might be valuable to general physicians and ophthalmologists when there is a diagnosis of age-related cataract and should be collected on a routine basis in eye clinics.
PURPOSE: To evaluate the association between different amounts of alcohol consumption and the risk of age-related cataract. METHODS: We searched PubMed and Embase from their inception until May 2014 for case-control or cohort studies with data on alcohol consumption and age-related cataract. Heavy alcohol consumption was defined as more than two standard drinks per day, which is equal to a daily intake of 20 g of alcohol or 140 g per week. Moderate consumption was defined as less than 20 g of alcohol per day but more than never any. We performed separate meta-analyses for the associations of moderate or heavy alcohol consumption with age-related cataract under a random-effects model, respectively. RESULTS: Five case-control and five cohort studies were identified through comprehensive literature search. In the meta-analysis of 10 studies, the associations between moderate alcohol consumption and age-related cataract were marginally nonsignificant (pooled relative risk, 0.88; 95% confidence interval, 0.74 to 1.05; I = 82.1%), whereas heavy alcohol consumption was associated with an increased risk of age-related cataract (pooled relative risk, 1.26; 95% confidence interval, 1.06 to 1.50; I = 58.9%). The association between heavy alcohol consumption and cataract was stronger in case-control than in cohort studies. Adjusting for smoking as a potential confounder attenuated the association between heavy alcohol consumption and cataract. CONCLUSIONS: Heavy alcohol consumption significantly increased the risk of age-related cataract, whereas moderate consumption may be protective for this ocular condition. Clinically, information on a patient's alcohol drinking history might be valuable to general physicians and ophthalmologists when there is a diagnosis of age-related cataract and should be collected on a routine basis in eye clinics.
Authors: Sharon Y L Chua; Robert N Luben; Shabina Hayat; David C Broadway; Kay-Tee Khaw; Alasdair Warwick; Abigail Britten; Alexander C Day; Nicholas Strouthidis; Praveen J Patel; Peng T Khaw; Paul J Foster; Anthony P Khawaja Journal: Ophthalmology Date: 2021-02-08 Impact factor: 12.079
Authors: Nancy Phaswana-Mafuya; Karl Peltzer; Amelia Crampin; Edmund Ahame; Zinhle Sokhela Journal: Int J Environ Res Public Health Date: 2017-12-06 Impact factor: 3.390