AIM: Several synthetic peptide manipulations during the time surrounding birth can alter the specific neurohormonal status in the newborn brain. This study is aimed at assessing whether intrapartum oxytocin administration has any effect on primitive neonatal reflexes and determining whether such an effect is dose-dependent. MATERIALS AND METHODS: A cohort prospective study was conducted at a tertiary hospital. Mother-infant dyads who received intrapartum oxytocin (n=53) were compared with mother-infant dyads who did not receive intrapartum oxytocin (n=45). Primitive neonatal reflexes (endogenous, antigravity, motor, and rhythmic reflexes) were quantified by analyzing videotaped breastfeeding sessions in a biological nurturing position. Two observers blind to the group assignment and the oxytocin dose analyzed the videotapes and assesed the newborn's state of consciousness according to the Brazelton scale. RESULTS: The release of all rhythmic reflexes (p=0.01), the antigravity reflex (p=0.04), and total primitive neonatal reflexes (p=0.02) in the group exposed to oxytocin was lower than in the group not exposed to oxytocin. No correlations were observed between the dose of oxytocin administered and the percentage of primitive neonatal reflexes released (r=0.03; p=0.82). CONCLUSIONS: Intrapartum oxytocin administration might inhibit the expression of several primitive neonatal reflexes associated with breastfeeding. This correlation does not seem to be dose-dependent.
AIM: Several synthetic peptide manipulations during the time surrounding birth can alter the specific neurohormonal status in the newborn brain. This study is aimed at assessing whether intrapartum oxytocin administration has any effect on primitive neonatal reflexes and determining whether such an effect is dose-dependent. MATERIALS AND METHODS: A cohort prospective study was conducted at a tertiary hospital. Mother-infant dyads who received intrapartum oxytocin (n=53) were compared with mother-infant dyads who did not receive intrapartum oxytocin (n=45). Primitive neonatal reflexes (endogenous, antigravity, motor, and rhythmic reflexes) were quantified by analyzing videotaped breastfeeding sessions in a biological nurturing position. Two observers blind to the group assignment and the oxytocin dose analyzed the videotapes and assesed the newborn's state of consciousness according to the Brazelton scale. RESULTS: The release of all rhythmic reflexes (p=0.01), the antigravity reflex (p=0.04), and total primitive neonatal reflexes (p=0.02) in the group exposed to oxytocin was lower than in the group not exposed to oxytocin. No correlations were observed between the dose of oxytocin administered and the percentage of primitive neonatal reflexes released (r=0.03; p=0.82). CONCLUSIONS: Intrapartum oxytocin administration might inhibit the expression of several primitive neonatal reflexes associated with breastfeeding. This correlation does not seem to be dose-dependent.
Authors: S Phaneuf; G Asbóth; M P Carrasco; G N Europe-Finner; F Saji; T Kimura; A Harris; A López Bernal Journal: J Endocrinol Date: 1997-07 Impact factor: 4.286
Authors: H G Dahlen; H P Kennedy; C M Anderson; A F Bell; A Clark; M Foureur; J E Ohm; A M Shearman; J Y Taylor; M L Wright; S Downe Journal: Med Hypotheses Date: 2013-02-12 Impact factor: 1.538
Authors: Pedro García-Fortea; Ernesto González-Mesa; Marta Blasco; Olga Cazorla; M Delgado-Ríos; María J González-Valenzuela Journal: J Matern Fetal Neonatal Med Date: 2014-01-13
Authors: Karen L Bales; Antoniah D Lewis-Reese; Lisa A Pfeifer; Kristin M Kramer; C Sue Carter Journal: Dev Psychobiol Date: 2007-05 Impact factor: 3.038
Authors: Karen L Bales; Julie A van Westerhuyzen; Antoniah D Lewis-Reese; Nathaniel D Grotte; Jalene A Lanter; C Sue Carter Journal: Horm Behav Date: 2007-05-10 Impact factor: 3.587