| Literature DB >> 25785367 |
João Nobrega de Almeida Júnior1, Renata Buccheri de Oliveira2, Amaro Duarte3, Adriana Lopes Motta1, Flávia Rossi1, Dulce Sachiko Yamamoto de Figueiredo1, Gilda Maria Barbaro Del Negro2, Valeria Aoki4, Celina Wakisaka Maruta4, Claudia Giuli Santi4, Gil Benard2.
Abstract
IMPORTANCE: To our knowledge, these are the first reports of bloodstream infections by Trichosporon inkin in patients with pemphigus. OBSERVATIONS: Trichosporon inkin, a novel organism causing bloodstream infection, was detected in 2 patients with pemphigus. An elderly man with pemphigus foliaceus died despite treatment with liposomal amphotericin B, 3 mg/kg/d, and a young girl with pemphigus vulgaris responded to treatment with voriconazole, 8 mg/kg/d, for 24 days. One of the T inkin isolates had a minimal inhibitory concentration of 2 mg/L against amphotericin B, suggesting resistance to the drug. CONCLUSIONS AND RELEVANCE: Delayed suspicion of invasive infection by T inkin may result in a poor outcome in patients with severe forms of pemphigus. This opportunistic infection is highly refractory to conventional potent antifungal treatment.Entities:
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Year: 2015 PMID： 25785367 DOI： 10.1001/jamadermatol.2014.5462
Source DB: PubMed Journal: JAMA Dermatol ISSN： 2168-6068 Impact factor: 10.282