Tu Hu1, Qingcheng Yang1, Jing Xu2, Zhichang Zhang1, Nengbin He1, Yuzhen Du2. 1. Department of Orthopedics, Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai, China. 2. Department of Laboratory Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai, China.
Abstract
INTRODUCTION: Few serum markers are valid and useful for the diagnosis or therapeutic effect monitoring of osteosarcoma. This study aimed to investigate the role of β-isomerized C-terminal telopeptides (β-CTx) and total procollagen type 1 amino-terminal propeptide (tP1NP) as serological biomarkers for osteosarcoma patients. MATERIALS AND METHODS: A total of 48 patients with osteosarcoma and 55 healthy volunteers were investigated. Serum β-CTx and tP1NP levels were measured by electrochemiluminescence immunoassay. Data were analyzed by t test with Walth's correction and receiver operating characteristic (ROC) curve analysis. RESULTS: The baseline levels of β-CTx and tP1NP were found to be significantly higher in patients with osteosarcoma than the healthy volunteers. The mean areas under the ROC curves were 0.919 (range, 0.864-0.973) for β-CTx and 0.866 (range, 0.792-0.939) for tP1NP. The levels of β-CTx and tP1NP were lower in patients with stable disease after operation than those before operation. CONCLUSION: These findings support our hypothesis that β-CTx and tP1NP are promising serum biomarkers for diagnosing or monitoring osteosarcoma.
INTRODUCTION: Few serum markers are valid and useful for the diagnosis or therapeutic effect monitoring of osteosarcoma. This study aimed to investigate the role of β-isomerized C-terminal telopeptides (β-CTx) and total procollagen type 1 amino-terminal propeptide (tP1NP) as serological biomarkers for osteosarcomapatients. MATERIALS AND METHODS: A total of 48 patients with osteosarcoma and 55 healthy volunteers were investigated. Serum β-CTx and tP1NP levels were measured by electrochemiluminescence immunoassay. Data were analyzed by t test with Walth's correction and receiver operating characteristic (ROC) curve analysis. RESULTS: The baseline levels of β-CTx and tP1NP were found to be significantly higher in patients with osteosarcoma than the healthy volunteers. The mean areas under the ROC curves were 0.919 (range, 0.864-0.973) for β-CTx and 0.866 (range, 0.792-0.939) for tP1NP. The levels of β-CTx and tP1NP were lower in patients with stable disease after operation than those before operation. CONCLUSION: These findings support our hypothesis that β-CTx and tP1NP are promising serum biomarkers for diagnosing or monitoring osteosarcoma.
Entities:
Keywords:
Osteosarcoma; bone marker; diagnosis; monitoring; serum
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