Feryal Karaca1, Cigdem Usul Afsar2, Meral Gunaldi2, Erkut Erkurt1, Vehbi Ercolak2, Yasar Sertdemir3, Semra Paydas2. 1. Department of Radiation Oncology, Faculty of Medicine, Cukurova University Adana, Turkey. 2. Department of Medical Oncology, Faculty of Medicine, Cukurova University Adana, Turkey. 3. Department of Biostatistic, Faculty of Medicine, Cukurova University Adana, Turkey.
Abstract
AIM: This study involved 30 patients (16 had gastric, 9 pancreatic and 5 gall bladder cancer) who had received concomitant chemoradiotherapy (CRT). Blood ghrelin and IL-6 values were compared before, in the last week of, and 3 months after CRT. Meanwhile, changes in body weight of patients were also investigated with changes in ghrelin and IL-6 levels before, in the last week of, and after radiotherapy (RT). METHODS: Informed consent of the patients and the ethical committee approval from Cukurova University Medical Faculty were taken. Blood ghrelin and IL-6 levels were measured by using the ELISA method. Survival analysis was performed by the Kaplan Maier method, and data were evaluated by using the SPSS 19.0 package. Categorical measurements were calculated as numbers and percentages, whereas numerical data were summarized as mean and standard deviation. RESULTS: The correlation between ghrelin and IL-6 values at the baseline of RT and overall survival rates at the end of the 30-month follow up was analyzed. Accordingly, ghrelin values were also changed in line with changes in patients' weights (P < 0.001). Patients with ghrelin values above 35 pg/ml before RT had longer survival rates at the end of the 30-month follow up (P = 0.001). Overall survival rates in patients with IL-6 value at or below 3.9 pg/ml before RT were longer than patients with IL-6 value above 3.9 pg/ml (P = 0.021). CONCLUSION: Therefore, the initiation of ghrelin analogue prophylactically in patients receiving chemoradiotherapy with gastrointestinal system malignancies can both prevent weight loss by increasing appetite and decrease severity of inflammation, thereby increasing survival.
AIM: This study involved 30 patients (16 had gastric, 9 pancreatic and 5 gall bladder cancer) who had received concomitant chemoradiotherapy (CRT). Blood ghrelin and IL-6 values were compared before, in the last week of, and 3 months after CRT. Meanwhile, changes in body weight of patients were also investigated with changes in ghrelin and IL-6 levels before, in the last week of, and after radiotherapy (RT). METHODS: Informed consent of the patients and the ethical committee approval from Cukurova University Medical Faculty were taken. Blood ghrelin and IL-6 levels were measured by using the ELISA method. Survival analysis was performed by the Kaplan Maier method, and data were evaluated by using the SPSS 19.0 package. Categorical measurements were calculated as numbers and percentages, whereas numerical data were summarized as mean and standard deviation. RESULTS: The correlation between ghrelin and IL-6 values at the baseline of RT and overall survival rates at the end of the 30-month follow up was analyzed. Accordingly, ghrelin values were also changed in line with changes in patients' weights (P < 0.001). Patients with ghrelin values above 35 pg/ml before RT had longer survival rates at the end of the 30-month follow up (P = 0.001). Overall survival rates in patients with IL-6 value at or below 3.9 pg/ml before RT were longer than patients with IL-6 value above 3.9 pg/ml (P = 0.021). CONCLUSION: Therefore, the initiation of ghrelin analogue prophylactically in patients receiving chemoradiotherapy with gastrointestinal system malignancies can both prevent weight loss by increasing appetite and decrease severity of inflammation, thereby increasing survival.
Authors: Miriam Granado; Teresa Priego; Ana I Martín; M Angeles Villanúa; Asunción López-Calderón Journal: Am J Physiol Endocrinol Metab Date: 2004-10-26 Impact factor: 4.310
Authors: H Ariyasu; K Takaya; T Tagami; Y Ogawa; K Hosoda; T Akamizu; M Suda; T Koh; K Natsui; S Toyooka; G Shirakami; T Usui; A Shimatsu; K Doi; H Hosoda; M Kojima; K Kangawa; K Nakao Journal: J Clin Endocrinol Metab Date: 2001-10 Impact factor: 5.958
Authors: Wei Gen Li; Dan Gavrila; Xuebo Liu; Lixing Wang; Skuli Gunnlaugsson; Lynn L Stoll; Michael L McCormick; Curt D Sigmund; Chaosu Tang; Neal L Weintraub Journal: Circulation Date: 2004-04-26 Impact factor: 29.690