Jingwu Li1, Jianzhong Cui2, Jinghua Zhang3, Yuanting Liu3, Longcai Han3, Chunliang Jia3, Jingyu Deng4, Han Liang4. 1. Section of Surgery Teaching and Research, Hebei Medical University Shijiazhuang, Hebei Province, China ; Department of Surgical Oncology, Tangshan People's Hospital Tangshan, Hebei Province, China. 2. Section of Surgery Teaching and Research, Hebei Medical University Shijiazhuang, Hebei Province, China. 3. Department of Surgical Oncology, Tangshan People's Hospital Tangshan, Hebei Province, China. 4. Department of Gastric Cancer Surgery, Tianjin Medical University Cancer Hospital Tianjin, China.
Abstract
OBJECTIVE: The present study was conducted to elucidate the prognostic prediction value of the expression of the protein inhibitor of activated signal transducer and activators of transcription 3 (PIAS3) in gastric cancer (GC). METHODS: We detected the expression of PIAS3 in GC tissue, adjacent non-tumor tissue, GC cell lines, and GES-1 cell line. Besides, both clinicopathological data and follow-up records were obtained for patients' survival analyses. RESULTS: We showed that both protein and mRNA expression of PIAS3 in GC tissue were significantly lower than those in adjacent non-tumor tissue, respectively. Besides, the relative mRNA expression value of PIAS3 in each of GC cell lines was also much lower than that in GES-1 cell line. With multivariate survival analyses, PIAS3 protein expression in GC tissues, and status of lymph node metastasis were identified to be the independently prognostic predictors of GC by using the Cox regression with bootstrapping method. CONCLUSIONS: Lower expression of PIAS3 protein, indicating the poor survival of GC, is a potential marker for prediction the prognosis of patients.
OBJECTIVE: The present study was conducted to elucidate the prognostic prediction value of the expression of the protein inhibitor of activated signal transducer and activators of transcription 3 (PIAS3) in gastric cancer (GC). METHODS: We detected the expression of PIAS3 in GC tissue, adjacent non-tumor tissue, GC cell lines, and GES-1 cell line. Besides, both clinicopathological data and follow-up records were obtained for patients' survival analyses. RESULTS: We showed that both protein and mRNA expression of PIAS3 in GC tissue were significantly lower than those in adjacent non-tumor tissue, respectively. Besides, the relative mRNA expression value of PIAS3 in each of GC cell lines was also much lower than that in GES-1 cell line. With multivariate survival analyses, PIAS3 protein expression in GC tissues, and status of lymph node metastasis were identified to be the independently prognostic predictors of GC by using the Cox regression with bootstrapping method. CONCLUSIONS: Lower expression of PIAS3 protein, indicating the poor survival of GC, is a potential marker for prediction the prognosis of patients.
Entities:
Keywords:
Stomach; lymph node; neoplasm; protein inhibitor of activated signal transducer and activators of transcription 3; survival
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