| Literature DB >> 25785001 |
Ethem Unal1, Suleyman Atalay2, Huseyin Kerem Tolan1, Sema Yuksekdag1, Metin Yucel1, Aylin Acar1, Fatih Basak1, Pembegul Gunes3, Gurhan Bas1.
Abstract
In the present study, we described an easily reproducable experimental pancreatits model induced by biliopancreatic duct injection of ethyl alcohol. Seventy Wistar albino rats were divided equally into seven groups randomly: the control group (group 1), acute pancreatitis groups; induced by 20% ethanol (group 2), 48% ethanol (group 3), 80% ethanol (group 4), chronic pancreatitis groups; induced by 20% ethanol (group 5), 48% ethanol (group 6) and by 80% ethanol (group 7). Acute pancreatitis groups were sacrified on postoperative day 3, while the control group and chronic pancreatitis groups were killed on postoperative day 7. Histopathologic evaluation was done, and P < 0.05 was accepted as statistically significant. All rats in group 3 developed acute pancreatitis (100%). Inflammatory infiltration of neutrophils and mononuclear cells, interstitial edema, and focal necrotic areas were seen in the pancreatic tissues. Similarly, all rats in group 6 developed chronic pancreatitis (100%). Interstitial fibrosis, lymphotic infiltration, ductal dilatation, acinar cell atrophy, periductal hyperplasia were seen in the pancreatic tissues. Mortality was seen only in group 7. The biliopancreatic ductal injection of 48% ethanol induced acute and chronic pancreatitis has 100% success rate.Entities:
Keywords: Experimental; acute pancreatitis; animal model; chronic pancreatitis; ethanol
Year: 2015 PMID： 25785001 PMCID： PMC4358456
Source DB: PubMed Journal: Int J Clin Exp Med ISSN： 1940-5901