Yasuyuki Maruse1, Shintaro Kawano1, Tamotsu Kiyoshima2, Yuichi Goto1, Ryota Matsubara1, Toru Chikui3, Daigo Yoshiga1, Seiji Nakamura1. 1. Section of Oral and Maxillofacial Oncology, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University, Fukuoka, Japan. 2. Laboratory of Oral Pathology, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University, Fukuoka, Japan. 3. Department of Oral and Maxillofacial Radiology, Faculty of Dental Science, Kyushu University, Fukuoka, Japan.
Abstract
BACKGROUND: Mucoepidermoid carcinoma (MEC) is the most common salivary gland malignancy. Although the histopathological findings are diverse, no case of salivary MEC accompanied with bone formation has been reported. Herein, we present the first case of MEC with intratumoral bone formation. METHODS AND RESULTS: A case of a 75-year-old female patient with an asymptomatic mass of the oral floor is presented. Enhanced CT revealed a tumorous mass with radiopaque materials in the oral floor. A pathological diagnosis of MEC was obtained by biopsy. Radical surgery was performed with the patient under general anesthesia. The resected specimen was finally diagnosed as MEC. Histopathologically, hyalinization, and dystrophic calcification were conspicuous within the stromal components of the tumor. Interestingly, ectopic bone formation was also found in the tumor tissues. Bony materials with osteocyte-like cells were also observed in a series of dystrophic calcification. CONCLUSION: These findings suggest that bony materials are associated with dystrophic calcification.
BACKGROUND:Mucoepidermoid carcinoma (MEC) is the most common salivary gland malignancy. Although the histopathological findings are diverse, no case of salivary MEC accompanied with bone formation has been reported. Herein, we present the first case of MEC with intratumoral bone formation. METHODS AND RESULTS: A case of a 75-year-old female patient with an asymptomatic mass of the oral floor is presented. Enhanced CT revealed a tumorous mass with radiopaque materials in the oral floor. A pathological diagnosis of MEC was obtained by biopsy. Radical surgery was performed with the patient under general anesthesia. The resected specimen was finally diagnosed as MEC. Histopathologically, hyalinization, and dystrophic calcification were conspicuous within the stromal components of the tumor. Interestingly, ectopic bone formation was also found in the tumor tissues. Bony materials with osteocyte-like cells were also observed in a series of dystrophic calcification. CONCLUSION: These findings suggest that bony materials are associated with dystrophic calcification.
Authors: Nolan B Seim; Ramez H W Philips; Lynn Schoenfield; Theodoros N Teknos; James W Rocco; Amit Agrawal; Enver Ozer; Ricardo L Carrau; Stephen Y Kang; Matthew O Old Journal: Head Neck Pathol Date: 2017-03-27