Sumitra S Khandelwal1, J Bradley Randleman. 1. aBaylor College of Medicine, Cullen Eye Institute, Houston, Texas, USA bDepartment of Ophthalmology, Emory University cEmory Vision, Emory Eye Center, Atlanta, Georgia, USA.
Abstract
PURPOSE OF REVIEW: To review current concepts and future directions of corneal cross-linking (CXL) as a treatment for keratoconus, ectasia after refractive surgery and infectious keratitis. RECENT FINDINGS: Several important laboratory and clinical studies have established the safety and success of corneal cross-linking for the treatment of keratoconus and other corneal ectasias. Recently, additional studies have analyzed new directions and controversies in corneal cross-linking, exploring new indications, comparing new techniques and analyzing results of new protocols. SUMMARY: The results of bench and clinical research are providing the foundation to allow for protocol modifications of the standard cross-linking protocols and expansion of cross-linking concepts for techniques such as accelerated cross-linking, epithelium-sparing protocols and measurement of progression and success.
PURPOSE OF REVIEW: To review current concepts and future directions of corneal cross-linking (CXL) as a treatment for keratoconus, ectasia after refractive surgery and infectious keratitis. RECENT FINDINGS: Several important laboratory and clinical studies have established the safety and success of corneal cross-linking for the treatment of keratoconus and other corneal ectasias. Recently, additional studies have analyzed new directions and controversies in corneal cross-linking, exploring new indications, comparing new techniques and analyzing results of new protocols. SUMMARY: The results of bench and clinical research are providing the foundation to allow for protocol modifications of the standard cross-linking protocols and expansion of cross-linking concepts for techniques such as accelerated cross-linking, epithelium-sparing protocols and measurement of progression and success.
Authors: Shira Hed; Ran Matlov Kormas; Sagi Shashar; Boris E Malyugin; Matthew Boyko; Boris Knyazer Journal: J Ophthalmol Date: 2021-11-03 Impact factor: 1.909