Literature DB >> 2578409

Bicuculline and picrotoxin block gamma-aminobutyric acid-gated Cl- conductance by different mechanisms.

N Akaike, K Hattori, Y Oomura, D O Carpenter.   

Abstract

Using isolated, internally perfused bullfrog dorsal root ganglion cells we have studied the dose-response curves for gamma-aminobutyric acid (GABA) in the presence of internally or externally applied GABA antagonists. With external application of antagonists the inhibition of the GABA current by bicuculline was competitive and that by picrotoxin was noncompetitive. Picrotoxin but not bicuculline blocked when internally perfused.

Entities:  

Mesh：

Substances：

Year:  1985        PMID： 2578409     DOI： 10.1007/bf02005880

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  12 in total

1.  Voltage clamping with a single microelectrode.

Authors:  W A Wilson; M M Goldner
Journal:  J Neurobiol       Date:  1975-07

2.  Glutamate and quisqualate noise in voltage-clamped locust muscle fibres.

Authors:  C R Anderson; S G Cull-Candy; R Miledi
Journal:  Nature       Date:  1976-05-13       Impact factor: 49.962

3.  Bicuculline and picrotoxin as antagonists of gamma-aminobutyrate and neuromuscular inhibition in the lobster.

Authors:  R P Shank; S F Pong; A R Freeman; L T Graham
Journal:  Brain Res       Date:  1974-05-31       Impact factor: 3.252

4.  Junctional and extrajunctional membrane channels activated by GABA in locust muscle fibres.

Authors:  S G Cull-Candy; R Miledi
Journal:  Proc R Soc Lond B Biol Sci       Date:  1981-03-27

5.  Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches.

Authors:  O P Hamill; A Marty; E Neher; B Sakmann; F J Sigworth
Journal:  Pflugers Arch       Date:  1981-08       Impact factor: 3.657

Review 6.  Acetylcholine receptor kinetics.

Authors:  P R Adams
Journal:  J Membr Biol       Date:  1981-02-28       Impact factor: 1.843

7.  Internal perfusion studies demonstrating GABA-induced chloride responses in frog primary afferent neurons.

Authors:  K Hattori; N Akaike; Y Oomura; S Kuraoka
Journal:  Am J Physiol       Date:  1984-03

8.  Characterization and ionic basis of GABA-induced depolarizations recorded in vitro from cat primary afferent neurones.

Authors:  J P Gallagher; H Higashi; S Nishi
Journal:  J Physiol       Date:  1978-02       Impact factor: 5.182

9.  A study of the action of picrotoxin on the inhibitory neuromuscular junction of the crayfish.

Authors:  A Takeuchi; N Takeuchi
Journal:  J Physiol       Date:  1969-11       Impact factor: 5.182

10.  The electrophysiology and pharmacology of lobster neuromuscular synapses.

Authors:  H GRUNDFEST; J P REUBEN; W H RICKLES
Journal:  J Gen Physiol       Date:  1959-07-20       Impact factor: 4.086
View more
  32 in total

1.  Three GABA receptor-mediated postsynaptic potentials in interneurons in the rat lateral geniculate nucleus.

Authors:  J J Zhu; F S Lo
Journal:  J Neurosci       Date:  1999-07-15       Impact factor: 6.167

2.  Single channels activated by high concentrations of GABA in superior cervical ganglion neurones of the rat.

Authors:  C F Newland; D Colquhoun; S G Cull-Candy
Journal:  J Physiol       Date:  1991-01       Impact factor: 5.182

3.  GABA(A) receptor antagonism increases NMDA receptor inhibition by isoflurane at a minimum alveolar concentration.

Authors:  Robert J Brosnan
Journal:  Vet Anaesth Analg       Date:  2011-05       Impact factor: 1.648

Review 4.  GABA-ρ receptors: distinctive functions and molecular pharmacology.

Authors:  Moawiah M Naffaa; Sandy Hung; Mary Chebib; Graham A R Johnston; Jane R Hanrahan
Journal:  Br J Pharmacol       Date:  2017-04-12       Impact factor: 8.739

5.  Effects of benzodiazepines and non-benzodiazepine compounds on the GABA-induced response in frog isolated sensory neurones.

Authors:  T Yakushiji; T Fukuda; Y Oyama; N Akaike
Journal:  Br J Pharmacol       Date:  1989-11       Impact factor: 8.739

6.  Direct activation of GABAA receptors by barbiturates in cultured rat hippocampal neurons.

Authors:  J M Rho; S D Donevan; M A Rogawski
Journal:  J Physiol       Date:  1996-12-01       Impact factor: 5.182

7.  Multiple mechanisms of picrotoxin block of GABA-induced currents in rat hippocampal neurons.

Authors:  K W Yoon; D F Covey; S M Rothman
Journal:  J Physiol       Date:  1993-05       Impact factor: 5.182

8.  Activation of Cl- channels by avermectin in rat cultured hippocampal neurons.

Authors:  B Schönrock; J Bormann
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1993-12       Impact factor: 3.000

9.  Multiple mechanisms of antagonism of gamma-aminobutyric acid (GABA) responses.

Authors:  N Akaike; T Yakushiji; N Tokutomi; D O Carpenter
Journal:  Cell Mol Neurobiol       Date:  1987-03       Impact factor: 5.046

10.  Non-reactivating effects of HI-6 on hippocampal neurotransmission.

Authors:  B P Melchers; A L van der Laaken; R W Busker; P L Bruijnzeel; H P Van Helden
Journal:  Arch Toxicol       Date:  1994       Impact factor: 5.153
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.