OBJECTIVE: To investigate the genetic contributors to ADHD sustained attention deficit among noradrenergic genes responsible for the synthesis (dopamine-β-hydroxylase gene, DBH), transport (norepinephrine transporter gene, NET1), reception (alpha-2A adrenergic receptor gene, ADRA2A), and metabolism (monoamine oxidase A gene, MAOA) of noradrenalin (NE). METHOD: A total of 456 children with ADHD and 108 normal controls were included in a digit cancellation test (DCT). DNA was collected from 242 participants and genotyped for 14 single nucleotide polymorphisms (SNPs) of noradrenergic genes. RESULTS: Compared with normal controls, children with ADHD showed a lower total score and higher mean error rate in the DCT, indicating poorer sustained attention function. Analysis of covariance showed an association between MAOA genotypes and ADHD performance in DCT, with poorer performance in risk allele carriers. No association was found for other noradrenergic genes. CONCLUSION: Children with ADHD presented with a sustained attention deficit compared with normal controls. The sustained attention deficit of children with ADHD may be associated with genetic variant of MAOA.
OBJECTIVE: To investigate the genetic contributors to ADHD sustained attention deficit among noradrenergic genes responsible for the synthesis (dopamine-β-hydroxylase gene, DBH), transport (norepinephrine transporter gene, NET1), reception (alpha-2A adrenergic receptor gene, ADRA2A), and metabolism (monoamine oxidase A gene, MAOA) of noradrenalin (NE). METHOD: A total of 456 children with ADHD and 108 normal controls were included in a digit cancellation test (DCT). DNA was collected from 242 participants and genotyped for 14 single nucleotide polymorphisms (SNPs) of noradrenergic genes. RESULTS: Compared with normal controls, children with ADHD showed a lower total score and higher mean error rate in the DCT, indicating poorer sustained attention function. Analysis of covariance showed an association between MAOA genotypes and ADHD performance in DCT, with poorer performance in risk allele carriers. No association was found for other noradrenergic genes. CONCLUSION:Children with ADHD presented with a sustained attention deficit compared with normal controls. The sustained attention deficit of children with ADHD may be associated with genetic variant of MAOA.
Authors: Ariel F Martinez; Yu Abe; Sungkook Hong; Kevin Molyneux; David Yarnell; Heiko Löhr; Wolfgang Driever; Maria T Acosta; Mauricio Arcos-Burgos; Maximilian Muenke Journal: Biol Psychiatry Date: 2016-07-14 Impact factor: 13.382
Authors: Victor Marinho; Thomaz Oliveira; Juliete Bandeira; Giovanny R Pinto; Anderson Gomes; Valéria Lima; Francisco Magalhães; Kaline Rocha; Carla Ayres; Valécia Carvalho; Bruna Velasques; Pedro Ribeiro; Marco Orsini; Victor Hugo Bastos; Daya Gupta; Silmar Teixeira Journal: J Biomed Sci Date: 2018-08-07 Impact factor: 8.410