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Literature DB >> 25784043

Neurodegeneration: paying it off with sleep.

Abstract

A new study in fruit flies suggests modulation of neural activity links sleep and Alzheimer's disease. Both sleep loss and amyloid beta increase neural excitability, which reinforces the accumulation of amyloid beta and shortens lifespan.

Entities: Chemical Disease Gene Mutation Species

Mesh：

Substances：
Amyloid beta-Peptides

Year: 2015 PMID： 25784043 PMCID： PMC4381801 DOI： 10.1016/j.cub.2015.02.003

Source DB: PubMed Journal: Curr Biol ISSN： 0960-9822 Impact factor: 10.834

19 in total

1. The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Abeta protofibril formation.

Authors: C Nilsberth; A Westlind-Danielsson; C B Eckman; M M Condron; K Axelman; C Forsell; C Stenh; J Luthman; D B Teplow; S G Younkin; J Näslund; L Lannfelt
Journal: Nat Neurosci Date: 2001-09 Impact factor: 24.884

2. Endocytosis is required for synaptic activity-dependent release of amyloid-beta in vivo.

Authors: John R Cirrito; Jae-Eun Kang; Jiyeon Lee; Floy R Stewart; Deborah K Verges; Luz M Silverio; Guojun Bu; Steven Mennerick; David M Holtzman
Journal: Neuron Date: 2008-04-10 Impact factor: 17.173

3. Synaptic activity regulates interstitial fluid amyloid-beta levels in vivo.

Authors: John R Cirrito; Kelvin A Yamada; Mary Beth Finn; Robert S Sloviter; Kelly R Bales; Patrick C May; Darryle D Schoepp; Steven M Paul; Steven Mennerick; David M Holtzman
Journal: Neuron Date: 2005-12-22 Impact factor: 17.173

Review 4. Sleep and the price of plasticity: from synaptic and cellular homeostasis to memory consolidation and integration.

Authors: Giulio Tononi; Chiara Cirelli
Journal: Neuron Date: 2014-01-08 Impact factor: 17.173

Review 5. Sleep and Alzheimer disease pathology--a bidirectional relationship.

Authors: Yo-El S Ju; Brendan P Lucey; David M Holtzman
Journal: Nat Rev Neurol Date: 2013-12-24 Impact factor: 42.937

Review 6. Drosophila models of Alzheimer's amyloidosis: the challenge of dissecting the complex mechanisms of toxicity of amyloid-beta 42.

Authors: Koichi Iijima; Kanae Iijima-Ando
Journal: J Alzheimers Dis Date: 2008-12 Impact factor: 4.472

7. Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease.

Authors: Jorge J Palop; Jeannie Chin; Erik D Roberson; Jun Wang; Myo T Thwin; Nga Bien-Ly; Jong Yoo; Kaitlyn O Ho; Gui-Qiu Yu; Anatol Kreitzer; Steven Finkbeiner; Jeffrey L Noebels; Lennart Mucke
Journal: Neuron Date: 2007-09-06 Impact factor: 17.173

8. Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer's disease model.

Authors: Pascal E Sanchez; Lei Zhu; Laure Verret; Keith A Vossel; Anna G Orr; John R Cirrito; Nino Devidze; Kaitlyn Ho; Gui-Qiu Yu; Jorge J Palop; Lennart Mucke
Journal: Proc Natl Acad Sci U S A Date: 2012-08-06 Impact factor: 11.205