Jiechuan Ren1, Du Lei2, Tianhua Yang1, Dongmei An1, Fenglai Xiao1, Lei Li2, Xiaoqi Huang2, Qiyong Gong3, Dong Zhou4. 1. Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China. 2. Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China. 3. Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China. Electronic address: qiyonggong@hmrrc.org.cn. 4. Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China. Electronic address: zhoudong66@yahoo.de.
Abstract
PURPOSE: Paroxysmal kinesigenic dyskinesia (PKD) is a rare movement disorder. The underlying neural mechanisms have not been fully understood. This study aimed to examine the alteration of resting-state functional connectivity (RSFC) between interhemispheric homotopic regions in PKD using a technique called "voxel-mirrored homotopic connectivity" (VMHC). METHODS: The VMHC analysis was performed on resting-state functional MRI data from 11 PKD patients and 17 age and gender matched healthy subjects. Comparison between the two groups was conducted. The correlation relationship between VMHC and illness duration was analyzed. RESULTS: Compared with healthy subjects, PKD patients showed increased interhemispheric RSFC in bilateral putamen, primary motor cortex, supplementary motor area, dorsal lateral prefrontal cortex, primary somatosensory cortex, superior and middle occipital gyri, as well as cerebellar tonsil. Besides, negative correlation was detected between illness duration and VMHC in bilateral putamen and the insular cortex. CONCLUSION: The present study provided preliminary evidence of increased interhemispheric RSFC in PKD mainly in the basal ganglia-thalamo-cortical circuitry and cerebellum. A negative correlation between VMHC and illness duration was also detected. These findings could further enhance our understandings of the pathophysiology of PKD.
PURPOSE:Paroxysmal kinesigenic dyskinesia (PKD) is a rare movement disorder. The underlying neural mechanisms have not been fully understood. This study aimed to examine the alteration of resting-state functional connectivity (RSFC) between interhemispheric homotopic regions in PKD using a technique called "voxel-mirrored homotopic connectivity" (VMHC). METHODS: The VMHC analysis was performed on resting-state functional MRI data from 11 PKDpatients and 17 age and gender matched healthy subjects. Comparison between the two groups was conducted. The correlation relationship between VMHC and illness duration was analyzed. RESULTS: Compared with healthy subjects, PKDpatients showed increased interhemispheric RSFC in bilateral putamen, primary motor cortex, supplementary motor area, dorsal lateral prefrontal cortex, primary somatosensory cortex, superior and middle occipital gyri, as well as cerebellar tonsil. Besides, negative correlation was detected between illness duration and VMHC in bilateral putamen and the insular cortex. CONCLUSION: The present study provided preliminary evidence of increased interhemispheric RSFC in PKD mainly in the basal ganglia-thalamo-cortical circuitry and cerebellum. A negative correlation between VMHC and illness duration was also detected. These findings could further enhance our understandings of the pathophysiology of PKD.
Authors: Julián Benito-León; Elan D Louis; Eva Manzanedo; Juan Antonio Hernández-Tamames; Juan Álvarez-Linera; José Antonio Molina-Arjona; Michele Matarazzo; Juan Pablo Romero; Cristina Domínguez-González; Ángela Domingo-Santos; Álvaro Sánchez-Ferro Journal: Medicine (Baltimore) Date: 2016-07 Impact factor: 1.889
Authors: Julián Benito-León; Elan D Louis; Juan Pablo Romero; Juan Antonio Hernández-Tamames; Eva Manzanedo; Juan Álvarez-Linera; Félix Bermejo-Pareja; Ignacio Posada; Eduardo Rocon Journal: Medicine (Baltimore) Date: 2015-12 Impact factor: 1.817