Hadi Seikaly1, Vincent L Biron1, Han Zhang1, Daniel A O'Connell1, David W J Côté1, Khalid Ansari1, David C Williams2, Lakshmi Puttagunta3, Jeffrey R Harris1. 1. Division of Otolaryngology - Head and Neck Surgery, Department of Surgery, University of Alberta, Edmonton, Alberta, Canada. 2. Division of General Surgery, Department of Surgery, University of Alberta, Edmonton, Alberta, Canada. 3. Department of Laboratory Medicine and Pathology, University of Alberta, University of Alberta Hospital, Edmonton, Alberta, Canada.
Abstract
BACKGROUND: The purpose of this study was to compare survival outcomes of patients with advanced stage oropharyngeal squamous cell carcinoma (SCC) according to surgical and nonsurgical treatments, when stratified by smoking and p16 status. METHODS: We conducted a prospective longitudinal population-based study of 279 patients diagnosed with advanced oropharyngeal SCC. Patients were stratified by smoking and p16 status. RESULTS: There was no significant disease-specific survival (DSS) difference in combined modality treatment groups in nonsmokers that had p16-positive cancers, however, in smokers with p16-positive cancers, the DSS surgery + postoperative chemoradiotherapy (S+CRT) was significantly higher than chemoradiotherapy (CRT) alone. Patients who had p16-negative cancers had the highest DSS when treated with surgery + adjuvant therapy (S+RT)/CRT. Multivariate Cox regression analysis showed that increasing Eastern Cooperative Oncology Group (ECOG) score, smoking, p16 status, higher stage, and treatment with surgery protocols were significant determinants of survival. CONCLUSION: Primary surgical approaches offer the best survival outcomes in smokers with p16-positive cancers and in patients with p16-negative cancers.
BACKGROUND: The purpose of this study was to compare survival outcomes of patients with advanced stage oropharyngeal squamous cell carcinoma (SCC) according to surgical and nonsurgical treatments, when stratified by smoking and p16 status. METHODS: We conducted a prospective longitudinal population-based study of 279 patients diagnosed with advanced oropharyngeal SCC. Patients were stratified by smoking and p16 status. RESULTS: There was no significant disease-specific survival (DSS) difference in combined modality treatment groups in nonsmokers that had p16-positive cancers, however, in smokers with p16-positive cancers, the DSS surgery + postoperative chemoradiotherapy (S+CRT) was significantly higher than chemoradiotherapy (CRT) alone. Patients who had p16-negative cancers had the highest DSS when treated with surgery + adjuvant therapy (S+RT)/CRT. Multivariate Cox regression analysis showed that increasing Eastern Cooperative Oncology Group (ECOG) score, smoking, p16 status, higher stage, and treatment with surgery protocols were significant determinants of survival. CONCLUSION: Primary surgical approaches offer the best survival outcomes in smokers with p16-positive cancers and in patients with p16-negative cancers.
Authors: William R Kennedy; Michael P Herman; Rohan L Deraniyagala; Robert J Amdur; John W Werning; Peter Dziegielewski; Jessica Kirwan; Christopher G Morris; William M Mendenhall Journal: Eur Arch Otorhinolaryngol Date: 2016-04-08 Impact factor: 2.503
Authors: Shanmugappiriya Sivarajah; Andre Isaac; Tim Cooper; Han Zhang; Lakshmi Puttagunta; Jonathan Abele; Vincent Biron; Jeffery Harris; Hadi Seikaly; Daniel A O' Connell Journal: JAMA Otolaryngol Head Neck Surg Date: 2018-11-01 Impact factor: 6.223
Authors: Jessica Clark; Caroline C Jeffery; Han Zhang; Tim Cooper; Daniel A O'Connell; Jeffrey Harris; Hadi Seikaly; Vincent L Biron Journal: J Otolaryngol Head Neck Surg Date: 2015-09-15
Authors: Sherif Idris; Cameron Lindsay; Morris Kostiuk; Colin Andrews; David W J Côté; Daniel A O'Connell; Jeffrey Harris; Hadi Seikaly; Vincent L Biron Journal: J Otolaryngol Head Neck Surg Date: 2016-10-28
Authors: Vincent L Biron; Daniel A O'Connell; Brittany Barber; Jessica M Clark; Colin Andrews; Caroline C Jeffery; David W J Côté; Jeffrey Harris; Hadi Seikaly Journal: J Otolaryngol Head Neck Surg Date: 2017-03-14
Authors: Andre Isaac; Morris Kostiuk; Han Zhang; Cameron Lindsay; Fawaz Makki; Daniel A O'Connell; Jeffrey R Harris; David W J Cote; Hadi Seikaly; Vincent L Biron Journal: J Otolaryngol Head Neck Surg Date: 2017-01-14
Authors: Hani Z Marzouki; Vincent L Biron; Peter T Dziegielewski; Andrew Ma; Jason Vaz; Gabriela Constantinescu; Jeffrey Harris; Daniel O'Connell; Hadi Seikaly Journal: J Otolaryngol Head Neck Surg Date: 2018-09-19
Authors: Han Zhang; Michael Xie; Marc Levin; Stuart D Archibald; B Stanley Jackson; J E M Young; Michael K Gupta Journal: J Otolaryngol Head Neck Surg Date: 2019-09-02
Authors: Malak Jamal Gazzaz; Caroline Jeffery; Daniel O'Connell; Jeffery Harris; Hadi Seikaly; Vincent Biron Journal: Papillomavirus Res Date: 2019-10-16