| Literature DB >> 2578192 |
B Loev, H Jones, R E Brown, F C Huang, A Khandwala, M J Leibowitz, P Sonnino-Goldman.
Abstract
The synthesis of a series of [1,4]benzoxazine-2,3-diones and a new class of compounds, benzobisoxazinetetrones, is described. These compounds were evaluated for their effect in the rat mast cell (RMC) test passively sensitized in vitro with rat antiovalbumin serum and for their effect in inhibitory passive cutaneous anaphylaxis (PCA) in the rat. Some of these compounds are of the same potency level as disodium cromglycate in the RMC test and some are effective orally in PCA.Entities:
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Year: 1985 PMID： 2578192 DOI： 10.1021/jm00379a006
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446