| Literature DB >> 25781910 |
Zi-Hao Liu1, Xiao-Meng Dai, Bin Du.
Abstract
Hes1 is one mammalian counterpart of the Hairy and Enhancer of split proteins that play a critical role in many physiological processes including cellular differentiation, cell cycle arrest, apoptosis and self-renewal ability. Recent studies have shown that Hes1 functions in the maintenance of cancer stem cells (CSCs), metastasis and antagonizing drug-induced apoptosis. Pathways that are involved in the up-regulation of Hes1 level canonically or non-canonically, such as the Hedgehog, Wnt and hypoxia pathways are frequently aberrant in cancer cells. Here, we summarize the recent data supporting the idea that Hes1 may have an important function in the maintenance of cancer stem cells self-renewal, cancer metastasis, and epithelial-mesenchymal transition (EMT) process induction, as well as chemotherapy resistance, and conclude with the possible mechanisms by which Hes1 functions have their effect, as well as their crosstalk with other carcinogenic signaling pathways.Entities:
Keywords: ABC, ATP-binding cassette; CSCs, cancer stem cells; CSL, CBF1/ Suppressor of Hairless / Lag1; EMT, epithelial–mesenchymal transition; GSI, γ-secretase inhibitor; HDACs, histone deacetylases; Hes1; MAML, Mastermind-like protein family; MASH-1, Mammalian achaete-scute homolog-1; NICD, Notch intracellular domain; Notch signaling pathway; Runx2, Runt-related protein 2; TLE, transducin-like Enhancer of split; bHLH, basic helix-loop-helix; cancer stem cell; chemotherapy resistance; dnMAM, dominant-negative mastermind; metastasis; non-canonical Notch
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Year: 2015 PMID： 25781910 PMCID： PMC4622741 DOI： 10.1080/15384047.2015.1016662
Source DB: PubMed Journal: Cancer Biol Ther ISSN： 1538-4047 Impact factor: 4.742