Literature DB >> 25779969

Dual-pharmacophore DNA-encoded chemical libraries.

Jörg Scheuermann1, Dario Neri2.   

Abstract

In contrast to single-pharmacophore DNA-encoded libraries, where only one chemical moiety is linked to DNA, dual-pharmacophore DNA-encoded chemical libraries feature the display of two independent small-molecules in close proximity. This, in principle, allows to explore adjacent epitopes on a pharmaceutical target of choice and hence the discovery of simultaneously binding pairs of fragments, by virtue of the chelate effect.
Copyright © 2015 Elsevier Ltd. All rights reserved.

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Year:  2015        PMID： 25779969     DOI： 10.1016/j.cbpa.2015.02.021

Source DB:  PubMed          Journal:  Curr Opin Chem Biol        ISSN： 1367-5931            Impact factor:   8.822


  10 in total

1.  Kinetically guided radical-based synthesis of C(sp3)-C(sp3) linkages on DNA.

Authors:  Jie Wang; Helena Lundberg; Shota Asai; Pedro Martín-Acosta; Jason S Chen; Stephen Brown; William Farrell; Russell G Dushin; Christopher J O'Donnell; Anokha S Ratnayake; Paul Richardson; Zhiqing Liu; Tian Qin; Donna G Blackmond; Phil S Baran
Journal:  Proc Natl Acad Sci U S A       Date:  2018-06-26       Impact factor: 11.205

Review 2.  Advances in discovering small molecules to probe protein function in a systems context.

Authors:  Shelby K Doyle; Marius S Pop; Helen L Evans; Angela N Koehler
Journal:  Curr Opin Chem Biol       Date:  2015-11-23       Impact factor: 8.822

3.  Hit-Validation Methodologies for Ligands Isolated from DNA-Encoded Chemical Libraries.

Authors:  Gunther Zimmermann; Yizhou Li; Ulrike Rieder; Martin Mattarella; Dario Neri; Jörg Scheuermann
Journal:  Chembiochem       Date:  2017-01-30       Impact factor: 3.164

4.  Design, preparation, and selection of DNA-encoded dynamic libraries.

Authors:  Gang Li; Wenlu Zheng; Zitian Chen; Yu Zhou; Yu Liu; Junrui Yang; Yanyi Huang; Xiaoyu Li
Journal:  Chem Sci       Date:  2015-09-11       Impact factor: 9.825

Review 5.  Templated chemistry for bioorganic synthesis and chemical biology.

Authors:  Oliver Seitz
Journal:  J Pept Sci       Date:  2019-07       Impact factor: 1.905

6.  Modular assembly and encoding strategies for dual-display DNA-encoded chemical libraries.

Authors:  Sebastian Oehler; Louise Plais; Gabriele Bassi; Dario Neri; Jörg Scheuermann
Journal:  Chem Commun (Camb)       Date:  2021-11-19       Impact factor: 6.222

7.  Universal encoding of next generation DNA-encoded chemical libraries.

Authors:  Louise Plais; Alice Lessing; Michelle Keller; Adriano Martinelli; Sebastian Oehler; Gabriele Bassi; Dario Neri; Jörg Scheuermann
Journal:  Chem Sci       Date:  2022-01-11       Impact factor: 9.825

Review 8.  Recent advances in DNA-encoded dynamic libraries.

Authors:  Bingbing Shi; Yu Zhou; Xiaoyu Li
Journal:  RSC Chem Biol       Date:  2022-02-17

9.  Second-generation DNA-templated macrocycle libraries for the discovery of bioactive small molecules.

Authors:  Dmitry L Usanov; Alix I Chan; Juan Pablo Maianti; David R Liu
Journal:  Nat Chem       Date:  2018-04-02       Impact factor: 24.427

10.  C-N Coupling of DNA-Conjugated (Hetero)aryl Bromides and Chlorides for DNA-Encoded Chemical Library Synthesis.

Authors:  Ying-Chu Chen; John C Faver; Angela F Ku; Gabriella Miklossy; Kevin Riehle; Kurt M Bohren; Melek N Ucisik; Martin M Matzuk; Zhifeng Yu; Nicholas Simmons
Journal:  Bioconjug Chem       Date:  2020-02-21       Impact factor: 4.774
  10 in total

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