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Literature DB >> 25778927

Characterization of cyclic peptides containing disulfide bonds.

Mindy Johnson¹, Mingtao Liu¹, Elaine Struble¹, Kanthi Hettiarachchi².

Abstract

Unlike linear peptides, analysis of cyclic peptides containing disulfide bonds is not straightforward and demands indirect methods to achieve a rigorous proof of structure. Three peptides that belong to this category, p-Cl-Phe-DPDPE, DPDPE, and CTOP, were analyzed and the results are presented in this paper. The great potential of two dimensional NMR and ESI tandem mass spectrometry was harnessed during the course of peptide characterizations. A new RP-HPLC method for the analysis of trifluoroacetic acid is also presented. It is robust, simple, and efficient compared to the currently available methods.

Entities: CellLine Chemical Disease Gene Species

Keywords: Opioid peptides; RP-HPLC; Tandem mass spectrometry; Trifluoroacetic acid; Two-dimensional NMR

Mesh：

Substances：

Year: 2015 PMID： 25778927 PMCID： PMC4608431 DOI： 10.1016/j.jpba.2015.01.009

Source DB: PubMed Journal: J Pharm Biomed Anal ISSN： 0731-7085 Impact factor: 3.935

20 in total

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