| Literature DB >> 25777265 |
P C Nagajyothi1, Sang Ju Cha2, In Jun Yang1, T V M Sreekanth3, Kwang Joong Kim2, Heung Mook Shin4.
Abstract
The exploitation of various plant materials for the green synthesis of nanoparticles is considered an eco-friendly technology because it does not involve toxic chemicals. In this study, zinc oxide nanoparticles (ZnO NPs) were synthesized using the root extract of Polygala tenuifolia. Synthesized ZnO NPs were characterized by UV-Vis spectroscopy, FTIR, TGA, TEM, SEM and EDX. Anti-inflammatory activity was investigated in LPS-stimulated RAW 264.7 macrophages, whereas antioxidant activity was examined using a DPPH free radical assay. ZnO NPs demonstrated moderate antioxidant activity by scavenging 45.47% DPPH at 1mg/mL and revealed excellent anti-inflammatory activity by dose-dependently suppressing both mRNA and protein expressions of iNOS, COX-2, IL-1β, IL-6 and TNF-α.Entities:
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Year: 2015 PMID： 25777265 DOI： 10.1016/j.jphotobiol.2015.02.008
Source DB: PubMed Journal: J Photochem Photobiol B ISSN： 1011-1344 Impact factor: 6.252