Jennifer A E Doane1, Kerri Purdy2, Sylvia Pasternak2. 1. Departments of Medicine and Pathology, Capital District Health Authority and Dalhousie University, Halifax, NS jaedoane@dal.ca. 2. Departments of Medicine and Pathology, Capital District Health Authority and Dalhousie University, Halifax, NS.
Abstract
BACKGROUND: There are less than 100 cases of multinucleate cell angiohistiocytoma (MCA) currently reported in the literature. It occurs as a localized, asymptomatic, benign proliferation of the skin, characterized histologically by irregular multinucleate cells. Due to its novelty, the etiology of the disease and treatment options are still under investigation. OBJECTIVE: To report a case of confirmed, generalized MCA along with a review of the literature on the histology, immunology, potential etiology, and treatment of MCA. OBSERVATIONS: The patient was a 41-year-old female with asymptomatic violaceous plaques found on the extensor arms, legs, and trunk. Histopathology revealed increased dilated vascularity and cellularity (composed of mononuclear histiocytes and a few angulated multinucleated giant cells) in the dermis. CONCLUSIONS: Overall, MCA is a poorly understood, distinct dermatologic phenomenon. Here we present a case of generalized MCA to further the understanding of this disease presentation.
BACKGROUND: There are less than 100 cases of multinucleate cell angiohistiocytoma (MCA) currently reported in the literature. It occurs as a localized, asymptomatic, benign proliferation of the skin, characterized histologically by irregular multinucleate cells. Due to its novelty, the etiology of the disease and treatment options are still under investigation. OBJECTIVE: To report a case of confirmed, generalized MCA along with a review of the literature on the histology, immunology, potential etiology, and treatment of MCA. OBSERVATIONS: The patient was a 41-year-old female with asymptomatic violaceous plaques found on the extensor arms, legs, and trunk. Histopathology revealed increased dilated vascularity and cellularity (composed of mononuclear histiocytes and a few angulated multinucleated giant cells) in the dermis. CONCLUSIONS: Overall, MCA is a poorly understood, distinct dermatologic phenomenon. Here we present a case of generalized MCA to further the understanding of this disease presentation.
Authors: Anderson Alves Costa; Glaucia Ferreira Wedy; Walter Belda Junior; Paulo Ricardo Criado Journal: An Bras Dermatol Date: 2020-05-11 Impact factor: 1.896
Authors: Nora G Peterson; Benjamin M Stormo; Kevin P Schoenfelder; Juliet S King; Rayson Rs Lee; Donald T Fox Journal: Elife Date: 2020-10-14 Impact factor: 8.140