Prescilia Isedeh1, Ahmed Al Issa1, Henry W Lim1, Smita S Mulekar1, Sanjeev V Mulekar2. 1. Multicultural Dermatology Center, Department of Dermatology, Henry Ford Hospital, Detroit, MINational Center for Vitiligo & Psoriasis, Riyadh, Saudi ArabiaShetty Nursing Home, Mumbai, India. 2. Multicultural Dermatology Center, Department of Dermatology, Henry Ford Hospital, Detroit, MINational Center for Vitiligo & Psoriasis, Riyadh, Saudi ArabiaShetty Nursing Home, Mumbai, India mulekar@gmail.com.
Abstract
BACKGROUND: Patients with segmental vitiligo (SV), unlike those with nonsegmental vitiligo (NSV), have a more predictable course and are more responsive to surgery. OBJECTIVE: To report 10 patients with SV treated with the melanocyte-keratinocyte transplantation procedure (MKTP), who responded with unusual responses not previously reported in the literature. METHODS: This is a retrospective, observational study that reports 10 patients with SV who underwent the MKTP between May 2003 and May 2012. RESULTS: Two patients had successful repigmentation after split-thickness skin grafting after failure of the MKTP. Two patients developed a hypopigmented ring at a margin of the MKTP-treated area. One patient had complete repigmentation after a second MKTP. Two patients developed koebnerization of the recipient site. Three patients developed new vitiligo patches in previously unaffected areas after the MKTP. CONCLUSIONS: Uncommon and even suboptimal responses can occur following the MKTP in SV patients. There is a need for studies to provide better understanding and outcomes for SV patients undergoing the MKTP.
BACKGROUND:Patients with segmental vitiligo (SV), unlike those with nonsegmental vitiligo (NSV), have a more predictable course and are more responsive to surgery. OBJECTIVE: To report 10 patients with SV treated with the melanocyte-keratinocyte transplantation procedure (MKTP), who responded with unusual responses not previously reported in the literature. METHODS: This is a retrospective, observational study that reports 10 patients with SV who underwent the MKTP between May 2003 and May 2012. RESULTS: Two patients had successful repigmentation after split-thickness skin grafting after failure of the MKTP. Two patients developed a hypopigmented ring at a margin of the MKTP-treated area. One patient had complete repigmentation after a second MKTP. Two patients developed koebnerization of the recipient site. Three patients developed new vitiligo patches in previously unaffected areas after the MKTP. CONCLUSIONS: Uncommon and even suboptimal responses can occur following the MKTP in SV patients. There is a need for studies to provide better understanding and outcomes for SV patients undergoing the MKTP.